Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer's Disease
Copyright © 2020 Brem, Di Iorio, Fried, Oliveira-Maia, Marra, Profice, Quaranta, Schilberg, Atkinson, Seligson, Rossini and Pascual-Leone..
OBJECTIVE: To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training for treatment of cognitive symptoms in patients with Alzheimer's disease (AD). A secondary objective was to analyze associations between brain plasticity and cognitive effects of treatment.
METHODS: In this randomized, sham-controlled, multicenter clinical trial, 34 patients with AD were assigned to three experimental groups receiving 30 daily sessions of combinatory intervention. Participants in the real/real group (n = 16) received 10 Hz repetitive transcranial magnetic stimulation (rTMS) delivered separately to each of six cortical regions, interleaved with computerized cognitive training. Participants in the sham rTMS group (n = 18) received sham rTMS combined with either real (sham/real group, n = 10) or sham (sham/sham group, n = 8) cognitive training. Effects of treatment on neuropsychological (primary outcome) and neurophysiological function were compared between the 3 treatment groups. These, as well as imaging measures of brain atrophy, were compared at baseline to 14 healthy controls (HC).
RESULTS: At baseline, patients with AD had worse cognition, cerebral atrophy, and TMS measures of cortico-motor reactivity, excitability, and plasticity than HC. The real/real group showed significant cognitive improvement compared to the sham/sham, but not the real/sham group. TMS-induced plasticity at baseline was predictive of post-intervention changes in cognition, and was modified across treatment, in association with changes of cognition.
INTERPRETATION: Combined rTMS and cognitive training may improve the cognitive status of AD patients, with TMS-induced cortical plasticity at baseline serving as predictor of therapeutic outcome for this intervention, and potential mechanism of action.
CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier NCT01504958.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in aging neuroscience - 12(2020) vom: 04., Seite 200 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brem, Anna-Katharine [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer’s disease |
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| Anmerkungen: |
Date Revised 15.04.2022 published: Electronic-eCollection ClinicalTrials.gov: NCT01504958 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fnagi.2020.00200 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313087539 |
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| 245 | 1 | 0 | |a Corticomotor Plasticity Predicts Clinical Efficacy of Combined Neuromodulation and Cognitive Training in Alzheimer's Disease |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ClinicalTrials.gov: NCT01504958 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Brem, Di Iorio, Fried, Oliveira-Maia, Marra, Profice, Quaranta, Schilberg, Atkinson, Seligson, Rossini and Pascual-Leone. | ||
| 520 | |a OBJECTIVE: To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training for treatment of cognitive symptoms in patients with Alzheimer's disease (AD). A secondary objective was to analyze associations between brain plasticity and cognitive effects of treatment | ||
| 520 | |a METHODS: In this randomized, sham-controlled, multicenter clinical trial, 34 patients with AD were assigned to three experimental groups receiving 30 daily sessions of combinatory intervention. Participants in the real/real group (n = 16) received 10 Hz repetitive transcranial magnetic stimulation (rTMS) delivered separately to each of six cortical regions, interleaved with computerized cognitive training. Participants in the sham rTMS group (n = 18) received sham rTMS combined with either real (sham/real group, n = 10) or sham (sham/sham group, n = 8) cognitive training. Effects of treatment on neuropsychological (primary outcome) and neurophysiological function were compared between the 3 treatment groups. These, as well as imaging measures of brain atrophy, were compared at baseline to 14 healthy controls (HC) | ||
| 520 | |a RESULTS: At baseline, patients with AD had worse cognition, cerebral atrophy, and TMS measures of cortico-motor reactivity, excitability, and plasticity than HC. The real/real group showed significant cognitive improvement compared to the sham/sham, but not the real/sham group. TMS-induced plasticity at baseline was predictive of post-intervention changes in cognition, and was modified across treatment, in association with changes of cognition | ||
| 520 | |a INTERPRETATION: Combined rTMS and cognitive training may improve the cognitive status of AD patients, with TMS-induced cortical plasticity at baseline serving as predictor of therapeutic outcome for this intervention, and potential mechanism of action | ||
| 520 | |a CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov, identifier NCT01504958 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a clinical trial | |
| 650 | 4 | |a cognitive training | |
| 650 | 4 | |a combinatory intervention | |
| 650 | 4 | |a plasticity | |
| 650 | 4 | |a randomized controlled | |
| 650 | 4 | |a transcranial magnetic stimulation | |
| 700 | 1 | |a Di Iorio, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Fried, Peter J |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira-Maia, Albino J |e verfasserin |4 aut | |
| 700 | 1 | |a Marra, Camillo |e verfasserin |4 aut | |
| 700 | 1 | |a Profice, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Quaranta, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Schilberg, Lukas |e verfasserin |4 aut | |
| 700 | 1 | |a Atkinson, Natasha J |e verfasserin |4 aut | |
| 700 | 1 | |a Seligson, Erica E |e verfasserin |4 aut | |
| 700 | 1 | |a Rossini, Paolo Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual-Leone, Alvaro |e verfasserin |4 aut | |
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