Optimized set of criteria for defining interictal epileptiform EEG discharges
Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved..
OBJECTIVE: To find and validate the optimal combination of criteria that define interictal epileptiform EEG discharges (IEDs). Our target was a specificity over 95%, to avoid over-reading in clinical EEG.
METHODS: We constructed 63 combinations of the six criteria from the operational definition of IEDs, recently issued in the EEG-glossary of the International Federation of Clinical Neurophysiology (IFCN). The diagnostic gold standard was derived from video-EEG recordings. In a testing EEG dataset from 100 patients, we selected the best performing combinations of criteria and then we validated them in an independent dataset from 70 patients. We compared their performance with subjective, expert-scorings and we determined inter-rater agreement (IRA).
RESULTS: Without using criteria, the specificity of expert-scorings was lower than the pre-defined threshold (86%). The best performing combination of criteria was the following: waves with spiky morphology, followed by a slow-afterwave and voltage map suggesting a source in the brain. In the validation dataset this achieved a specificity of 97% and a sensitivity of 89%. IRA was substantial.
CONCLUSIONS: The optimized set of criteria for defining IEDs has high accuracy and IRA.
SIGNIFICANCE: Using these criteria will contribute to decreasing over-reading of EEG and avoid misdiagnosis of epilepsy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:131 |
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| Enthalten in: |
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 131(2020), 9 vom: 16. Sept., Seite 2250-2254 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kural, Mustafa Aykut [VerfasserIn] |
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| Links: |
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| Themen: |
Criteria |
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| Anmerkungen: |
Date Completed 25.05.2021 Date Revised 25.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clinph.2020.06.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM313067147 |
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| 500 | |a Date Revised 25.05.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: To find and validate the optimal combination of criteria that define interictal epileptiform EEG discharges (IEDs). Our target was a specificity over 95%, to avoid over-reading in clinical EEG | ||
| 520 | |a METHODS: We constructed 63 combinations of the six criteria from the operational definition of IEDs, recently issued in the EEG-glossary of the International Federation of Clinical Neurophysiology (IFCN). The diagnostic gold standard was derived from video-EEG recordings. In a testing EEG dataset from 100 patients, we selected the best performing combinations of criteria and then we validated them in an independent dataset from 70 patients. We compared their performance with subjective, expert-scorings and we determined inter-rater agreement (IRA) | ||
| 520 | |a RESULTS: Without using criteria, the specificity of expert-scorings was lower than the pre-defined threshold (86%). The best performing combination of criteria was the following: waves with spiky morphology, followed by a slow-afterwave and voltage map suggesting a source in the brain. In the validation dataset this achieved a specificity of 97% and a sensitivity of 89%. IRA was substantial | ||
| 520 | |a CONCLUSIONS: The optimized set of criteria for defining IEDs has high accuracy and IRA | ||
| 520 | |a SIGNIFICANCE: Using these criteria will contribute to decreasing over-reading of EEG and avoid misdiagnosis of epilepsy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Criteria | |
| 650 | 4 | |a Definition | |
| 650 | 4 | |a Diagnostic accuracy EEG | |
| 650 | 4 | |a Interictal epileptiform discharges | |
| 700 | 1 | |a Tankisi, Hatice |e verfasserin |4 aut | |
| 700 | 1 | |a Duez, Lene |e verfasserin |4 aut | |
| 700 | 1 | |a Sejer Hansen, Vibeke |e verfasserin |4 aut | |
| 700 | 1 | |a Udupi, Aparna |e verfasserin |4 aut | |
| 700 | 1 | |a Wennberg, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Rampp, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Larsson, Pål G |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, Reinhard |e verfasserin |4 aut | |
| 700 | 1 | |a Beniczky, Sándor |e verfasserin |4 aut | |
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