Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform
© 2020 The Authors. Published by Wiley-VCH GmbH..
We introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
Angewandte Chemie (International ed. in English) - 59(2020), 45 vom: 02. Nov., Seite 19951-19955 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Beloqui, Ana [VerfasserIn] |
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| Links: |
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| Themen: |
Bioconjugation |
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| Anmerkungen: |
Date Completed 29.03.2021 Date Revised 12.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/anie.202005747 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM31305245X |
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| 520 | |a © 2020 The Authors. Published by Wiley-VCH GmbH. | ||
| 520 | |a We introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Diels-Alder cycloaddition | |
| 650 | 4 | |a bioconjugation | |
| 650 | 4 | |a end group | |
| 650 | 4 | |a polymer | |
| 650 | 4 | |a protein | |
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| 700 | 1 | |a Mane, Shivshankar R |e verfasserin |4 aut | |
| 700 | 1 | |a Langer, Marcel |e verfasserin |4 aut | |
| 700 | 1 | |a Glassner, Mathias |e verfasserin |4 aut | |
| 700 | 1 | |a Bauer, Dennis M |e verfasserin |4 aut | |
| 700 | 1 | |a Fruk, Ljiljana |e verfasserin |4 aut | |
| 700 | 1 | |a Barner-Kowollik, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Delaittre, Guillaume |e verfasserin |4 aut | |
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