On the mechanism of ophiobolin F synthase and the absolute configuration of its product by isotopic labelling experiments

An ophiobolin F synthase homolog was discovered from Aspergillus calidoustus CBS121601. The cyclisation mechanism of this terpene synthase was investigated by extensive isotopic labelling experiments and the absolute configuration of its product ophiobolin F was elucidated by enantioselective deuteration.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Organic & biomolecular chemistry - 18(2020), 31 vom: 21. Aug., Seite 6072-6076

Sprache:

Englisch

Beteiligte Personen:

Quan, Zhiyang [VerfasserIn]
Dickschat, Jeroen S [VerfasserIn]

Links:

Volltext

Themen:

Alkyl and Aryl Transferases
EC 2.5.-
EC 2.5.1.-
Journal Article
Ophiobolin E
Ophiobolin F synthase, Aspergillus clavatus
Research Support, Non-U.S. Gov't
Sesterterpenes

Anmerkungen:

Date Completed 14.03.2022

Date Revised 14.03.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1039/d0ob01470b

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM313007012