Migraine and Two-Pore-Domain Potassium Channels

Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main subtypes: migraine with aura, when it is preceded by transient neurological disturbances due to cortical spreading depression (CSD), and migraine without aura. Activation and sensitization of trigeminal sensory neurons, leading to the release of pro-inflammatory peptides, is likely a key component in headache pain initiation and transmission in migraine. In the present review, we will focus on the function of two-pore-domain potassium (K2P) channels, which control trigeminal sensory neuron excitability and their potential interest for developing new drugs to treat migraine.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:27

Enthalten in:

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 27(2021), 3 vom: 04. Juni, Seite 268-284

Sprache:

Englisch

Beteiligte Personen:

Verkest, Clément [VerfasserIn]
Häfner, Stephanie [VerfasserIn]
Ávalos Prado, Pablo [VerfasserIn]
Baron, Anne [VerfasserIn]
Sandoz, Guillaume [VerfasserIn]

Links:

Volltext

Themen:

Allodynia
Excitability
Frameshift mutation-induced alternative translation initiation (fsATI)
Heterodimerization
Journal Article
K2P channels
KCNK
Kozac sequence
Migraine
Potassium Channels
Research Support, Non-U.S. Gov't
Review
Trigeminal sensory neurons

Anmerkungen:

Date Completed 17.01.2022

Date Revised 17.01.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1177/1073858420940949

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312917724