In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle

Utah Electrode Arrays (UEAs) have previously been characterized and implanted for neural recordings and stimulation at relatively low current levels. This proof-of-concept study investigated the applicability of UEAs in sub-surface cardiac pacing, for the first time, particularly to selectively sense and pace the His-Bundle (HB). HB pacing produces synchronous ventricular depolarization and improved cardiac function. Modified UEAs with sputtered iridium oxide film (SIROF) tips (100 - 150 μm) were characterized for SIROF delamination using an electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and voltage transient (VT) techniques at various current levels of up to 8 mA for a biphasic pulse with 1 ms duration per phase at 4 Hz. Our results indicate that at a short pacing duration of 20 s with current levels of up to 4 mA, the SIROF exhibited a strong charge-transfer performance. For the longer pacing duration (6 min), SIROF demonstrated its holding capacity at all current levels except for ≥2 mA when delamination commenced for the time exceeded 4 min (EIS) and 2 min (VT). UEAs were inserted in isolated, perfused goat hearts to record the HB electrograms in real-time. Both stimulated and unstimulated electrodes were characterized for SIROF delamination before, during and after in vivo work. Our findings indicate that UEA was stable during the heart's contraction and relaxation phase. Further, at a short pacing duration with current levels of up to 4 mA, UEA demonstrated high selectively in sensing the HB. This proof-of-concept work demonstrates the potential applicability of UEAs in cardiac applications.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:6

Enthalten in:

ACS biomaterials science & engineering - 6(2020), 6 vom: 08. Juni, Seite 3335-3348

Sprache:

Englisch

Beteiligte Personen:

Shah, Ankur R [VerfasserIn]
Khan, Muhammad S [VerfasserIn]
Hirahara, Annie M [VerfasserIn]
Lange, Matthias [VerfasserIn]
Ranjan, Ravi [VerfasserIn]
Dosdall, Derek J [VerfasserIn]

Links:

Volltext

Themen:

Cardiac
Electrochemical impedance spectroscopy
His Bundle
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Scanning electron microscopy
Sensing
Utah Electrode Array

Anmerkungen:

Date Completed 14.05.2021

Date Revised 09.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1021/acsbiomaterials.0c00065

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312909543