A novel nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma after salvage endoscopic surgery

Copyright © 2020 Elsevier Ltd. All rights reserved..

OBJECTIVES: To develop and validate a nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma (NPC) after salvage endoscopic surgery.

MATERIALS AND METHODS: A total of 229 eligible patients with recurrent NPC were divided into training (n = 115) and validation (n = 114) cohorts. A multivariate Cox proportional risk regression model was used to identify significant prognostic factors for overall survival (OS) in the training cohort. A nomogram was then developed based on the regression model. The performance of the nomogram was assessed with regard to discrimination and calibration. Patients were divided into low-risk or high-risk groups based on the risk scores derived from the nomogram. Furthermore, decision curve analysis (DCA) was used to assess the clinical utility of the nomogram.

RESULTS: Six significant predictors were identified: diabetes mellitus, body mass index (BMI), neutrophil-to-lymphocyte ratio (NLR), T stage, lymph node metastasis, and tumor necrosis. The nomogram incorporating these six predictors demonstrated favorable discrimination and calibration in the training cohort, with a C-index of 0.746 (95% confidence interval [CI] 0.656-0.836), which was subsequently confirmed in the validation cohort (C-index 0.768 [95% CI 0.675-0.861]). Furthermore, the nomogram successfully distinguished patients into low- and high-risk groups. DCA indicated that the nomogram was clinically useful.

CONCLUSIONS: The novel nomogram demonstrated its potential as an individual tool to predict survival in patients with recurrent NPC after salvage endoscopic surgery.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:111

Enthalten in:

Oral oncology - 111(2020) vom: 05. Dez., Seite 104922

Sprache:

Englisch

Beteiligte Personen:

Li, Wanpeng [VerfasserIn]
Lu, Hanyu [VerfasserIn]
Liu, Juan [VerfasserIn]
Liu, Quan [VerfasserIn]
Wang, Huan [VerfasserIn]
Zhang, Huankang [VerfasserIn]
Hu, Li [VerfasserIn]
Zhao, Weidong [VerfasserIn]
Gu, Yurong [VerfasserIn]
Li, Houyong [VerfasserIn]
Sun, Xicai [VerfasserIn]
Wang, Dehui [VerfasserIn]

Links:

Volltext

Themen:

Endoscopic surgery
Journal Article
Nasopharyngeal carcinoma
Nomogram
Recurrent
Research Support, Non-U.S. Gov't
Survival
Validation Study

Anmerkungen:

Date Completed 13.09.2021

Date Revised 13.09.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.oraloncology.2020.104922

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312885148