A novel nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma after salvage endoscopic surgery
Copyright © 2020 Elsevier Ltd. All rights reserved..
OBJECTIVES: To develop and validate a nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma (NPC) after salvage endoscopic surgery.
MATERIALS AND METHODS: A total of 229 eligible patients with recurrent NPC were divided into training (n = 115) and validation (n = 114) cohorts. A multivariate Cox proportional risk regression model was used to identify significant prognostic factors for overall survival (OS) in the training cohort. A nomogram was then developed based on the regression model. The performance of the nomogram was assessed with regard to discrimination and calibration. Patients were divided into low-risk or high-risk groups based on the risk scores derived from the nomogram. Furthermore, decision curve analysis (DCA) was used to assess the clinical utility of the nomogram.
RESULTS: Six significant predictors were identified: diabetes mellitus, body mass index (BMI), neutrophil-to-lymphocyte ratio (NLR), T stage, lymph node metastasis, and tumor necrosis. The nomogram incorporating these six predictors demonstrated favorable discrimination and calibration in the training cohort, with a C-index of 0.746 (95% confidence interval [CI] 0.656-0.836), which was subsequently confirmed in the validation cohort (C-index 0.768 [95% CI 0.675-0.861]). Furthermore, the nomogram successfully distinguished patients into low- and high-risk groups. DCA indicated that the nomogram was clinically useful.
CONCLUSIONS: The novel nomogram demonstrated its potential as an individual tool to predict survival in patients with recurrent NPC after salvage endoscopic surgery.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
---|---|
Enthalten in: |
Oral oncology - 111(2020) vom: 05. Dez., Seite 104922 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Wanpeng [VerfasserIn] |
---|
Links: |
---|
Themen: |
Endoscopic surgery |
---|
Anmerkungen: |
Date Completed 13.09.2021 Date Revised 13.09.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.oraloncology.2020.104922 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM312885148 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM312885148 | ||
003 | DE-627 | ||
005 | 20231225145355.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.oraloncology.2020.104922 |2 doi | |
028 | 5 | 2 | |a pubmed24n1042.xml |
035 | |a (DE-627)NLM312885148 | ||
035 | |a (NLM)32712576 | ||
035 | |a (PII)S1368-8375(20)30358-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Wanpeng |e verfasserin |4 aut | |
245 | 1 | 2 | |a A novel nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma after salvage endoscopic surgery |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 13.09.2021 | ||
500 | |a Date Revised 13.09.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
520 | |a OBJECTIVES: To develop and validate a nomogram to predict survival in patients with recurrent nasopharyngeal carcinoma (NPC) after salvage endoscopic surgery | ||
520 | |a MATERIALS AND METHODS: A total of 229 eligible patients with recurrent NPC were divided into training (n = 115) and validation (n = 114) cohorts. A multivariate Cox proportional risk regression model was used to identify significant prognostic factors for overall survival (OS) in the training cohort. A nomogram was then developed based on the regression model. The performance of the nomogram was assessed with regard to discrimination and calibration. Patients were divided into low-risk or high-risk groups based on the risk scores derived from the nomogram. Furthermore, decision curve analysis (DCA) was used to assess the clinical utility of the nomogram | ||
520 | |a RESULTS: Six significant predictors were identified: diabetes mellitus, body mass index (BMI), neutrophil-to-lymphocyte ratio (NLR), T stage, lymph node metastasis, and tumor necrosis. The nomogram incorporating these six predictors demonstrated favorable discrimination and calibration in the training cohort, with a C-index of 0.746 (95% confidence interval [CI] 0.656-0.836), which was subsequently confirmed in the validation cohort (C-index 0.768 [95% CI 0.675-0.861]). Furthermore, the nomogram successfully distinguished patients into low- and high-risk groups. DCA indicated that the nomogram was clinically useful | ||
520 | |a CONCLUSIONS: The novel nomogram demonstrated its potential as an individual tool to predict survival in patients with recurrent NPC after salvage endoscopic surgery | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Validation Study | |
650 | 4 | |a Endoscopic surgery | |
650 | 4 | |a Nasopharyngeal carcinoma | |
650 | 4 | |a Nomogram | |
650 | 4 | |a Recurrent | |
650 | 4 | |a Survival | |
700 | 1 | |a Lu, Hanyu |e verfasserin |4 aut | |
700 | 1 | |a Liu, Juan |e verfasserin |4 aut | |
700 | 1 | |a Liu, Quan |e verfasserin |4 aut | |
700 | 1 | |a Wang, Huan |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Huankang |e verfasserin |4 aut | |
700 | 1 | |a Hu, Li |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Weidong |e verfasserin |4 aut | |
700 | 1 | |a Gu, Yurong |e verfasserin |4 aut | |
700 | 1 | |a Li, Houyong |e verfasserin |4 aut | |
700 | 1 | |a Sun, Xicai |e verfasserin |4 aut | |
700 | 1 | |a Wang, Dehui |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Oral oncology |d 1998 |g 111(2020) vom: 05. Dez., Seite 104922 |w (DE-627)NLM091475074 |x 1879-0593 |7 nnns |
773 | 1 | 8 | |g volume:111 |g year:2020 |g day:05 |g month:12 |g pages:104922 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.oraloncology.2020.104922 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 111 |j 2020 |b 05 |c 12 |h 104922 |