Effect of fluoxetine at different concentrations on the adsorption behavior of Langmuir monolayers

Copyright © 2020 Elsevier B.V. All rights reserved..

Fluoxetine (FLX), approved for the treatment of depression and anxiety by the FDA in 2002, is an amphiphilic antidepressant. In general, amphiphilic drugs have high membrane permeability. Therefore, the interactions between these drugs and monolayers have been widely concerned. In this study, the adsorption of FLX on dipalmitoylphosphatidylcholine (DPPC) monolayers at different concentrations and surface pressures have been investigated by pressure-area isotherms (π-A), adsorption curves, compression-expansion curves, and atomic force microscopy (AFM). Our data showed that the adsorption behavior was related to the surface pressures and FLX concentrations in the subphase. The FLX that was added in the subphase under lower surface pressure (π = 10 mN/m) was easily adsorbed on DPPC monolayers. The stability of the monolayers was strong. The adsorption of FLX on DPPC monolayers and the stability decreased when π = 20 mN/m. In addition, the adsorption behavior and stability increased with increasing FLX concentrations. The AFM images of the monolayers confirmed the results of fitted adsorption curves. This study will be critical to our understanding of the interactions between drugs and lipid monolayers.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:1862

Enthalten in:

Biochimica et biophysica acta. Biomembranes - 1862(2020), 11 vom: 01. Nov., Seite 183418

Sprache:

Englisch

Beteiligte Personen:

Xie, Bin [VerfasserIn]
Hao, Changchun [VerfasserIn]
Sun, Runguang [VerfasserIn]

Links:

Volltext

Themen:

01K63SUP8D
1,2-Dipalmitoylphosphatidylcholine
2644-64-6
Adsorption behavior
DPPC monolayers
Fluoxetine
Journal Article
Research Support, Non-U.S. Gov't
Stability

Anmerkungen:

Date Completed 29.12.2020

Date Revised 29.12.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.bbamem.2020.183418

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312867875