Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

© 2020 Jian Zhang et al..

BACKGROUND: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals.

OBJECTIVE: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats.

DESIGN: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized.

RESULTS: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation.

CONCLUSIONS: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:64

Enthalten in:

Food & nutrition research - 64(2020) vom: 21.

Sprache:

Englisch

Beteiligte Personen:

Zhang, Jian [VerfasserIn]
Li, Wenhui [VerfasserIn]
Ying, Zhiwei [VerfasserIn]
Zhao, Di [VerfasserIn]
Yi, Guofu [VerfasserIn]
Li, He [VerfasserIn]
Liu, Xinqi [VerfasserIn]

Links:

Volltext

Themen:

Burn
Inflammation
Journal Article
Negative nitrogen balance
Nutritional supplement
Soybean protein-derived peptide

Anmerkungen:

Date Revised 15.04.2022

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.29219/fnr.v64.3677

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312711549