Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors
© 2020 Jian Zhang et al..
BACKGROUND: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals.
OBJECTIVE: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats.
DESIGN: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized.
RESULTS: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation.
CONCLUSIONS: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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Enthalten in: |
Food & nutrition research - 64(2020) vom: 21. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Zhang, Jian [VerfasserIn] |
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Links: |
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Themen: |
Burn |
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Anmerkungen: |
Date Revised 15.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.29219/fnr.v64.3677 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM312711549 |
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245 | 1 | 0 | |a Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors |
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500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2020 Jian Zhang et al. | ||
520 | |a BACKGROUND: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals | ||
520 | |a OBJECTIVE: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats | ||
520 | |a DESIGN: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized | ||
520 | |a RESULTS: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation | ||
520 | |a CONCLUSIONS: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients | ||
650 | 4 | |a Journal Article | |
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650 | 4 | |a nutritional supplement | |
650 | 4 | |a soybean protein-derived peptide | |
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700 | 1 | |a Zhao, Di |e verfasserin |4 aut | |
700 | 1 | |a Yi, Guofu |e verfasserin |4 aut | |
700 | 1 | |a Li, He |e verfasserin |4 aut | |
700 | 1 | |a Liu, Xinqi |e verfasserin |4 aut | |
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