The importance of indole and azaindole scaffold in the development of antitumor agents

Copyright © 2020 Elsevier Masson SAS. All rights reserved..

With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives. Combining structure activity relationships and molecular targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:203

Enthalten in:

European journal of medicinal chemistry - 203(2020) vom: 01. Okt., Seite 112506

Sprache:

Englisch

Beteiligte Personen:

Han, Yu [VerfasserIn]
Dong, Wei [VerfasserIn]
Guo, Qunqun [VerfasserIn]
Li, Xiufen [VerfasserIn]
Huang, Longjiang [VerfasserIn]

Links:

Volltext

Themen:

8724FJW4M5
Antineoplastic Agents
Antiproliferative activity
Antitumor activity
Aza Compounds
Azaindole derivatives
Cytotoxicity
Indole
Indole derivatives
Indoles
Journal Article
Review

Anmerkungen:

Date Completed 22.04.2021

Date Revised 22.04.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.ejmech.2020.112506

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312645147