The importance of indole and azaindole scaffold in the development of antitumor agents
Copyright © 2020 Elsevier Masson SAS. All rights reserved..
With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives. Combining structure activity relationships and molecular targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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Enthalten in: |
European journal of medicinal chemistry - 203(2020) vom: 01. Okt., Seite 112506 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Han, Yu [VerfasserIn] |
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Links: |
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Themen: |
8724FJW4M5 |
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Anmerkungen: |
Date Completed 22.04.2021 Date Revised 22.04.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.ejmech.2020.112506 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM312645147 |
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520 | |a With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives. Combining structure activity relationships and molecular targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents | ||
650 | 4 | |a Journal Article | |
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650 | 4 | |a Antiproliferative activity | |
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700 | 1 | |a Huang, Longjiang |e verfasserin |4 aut | |
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