Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates : a systematic review and meta-analysis
BACKGROUND: Evidence shows that fluconazole prophylaxis is an effective treatment against invasive fungal infections in preterm neonates, however, the most efficient schedule of fluconazole prophylaxis for the colonization and mortality of invasive candidiasis (IC) is unknown.
PURPOSE: This systematic review and meta-analysis aimed to assess the efficiency of different prophylactic fluconazole schedules in controlling IC colonization, infection, and mortality in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants in neonatal intensive care units.
METHODS: We searched the PubMed, Scopus, Embase, and Cochrane databases using the keywords "candida," "invasive candidiasis," "IC," "fluconazole prophylaxis," "preterm infants," "very low birth weight infants," "VLBW," "extremely low birth weight," and "ELBW.".
RESULTS: Mortality was significantly decreased in a metaanalysis of studies using different fluconazole prophylaxis regimens. The meta-analysis also indicated a significant decrease in the incidence of IC-associated mortality in ELBW infants using the same fluconazole prophylaxis schedules.
CONCLUSION: Future studies should explore the effectiveness of other different fluconazole prophylaxis schedules on IC colonization, infection, and mortality.
| Errataetall: |
CommentIn: Clin Exp Pediatr. 2021 Apr;64(4):167-168. - PMID 32683802 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Clinical and experimental pediatrics - 64(2021), 4 vom: 19. Apr., Seite 172-179 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Robati Anaraki, Mahmoud [VerfasserIn] |
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| Links: |
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| Themen: |
Extremely low birth weight |
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| Anmerkungen: |
Date Revised 15.04.2021 published: Print-Electronic CommentIn: Clin Exp Pediatr. 2021 Apr;64(4):167-168. - PMID 32683802 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3345/cep.2019.01431 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312601344 |
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| 245 | 1 | 0 | |a Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates |b a systematic review and meta-analysis |
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| 500 | |a Date Revised 15.04.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin Exp Pediatr. 2021 Apr;64(4):167-168. - PMID 32683802 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Evidence shows that fluconazole prophylaxis is an effective treatment against invasive fungal infections in preterm neonates, however, the most efficient schedule of fluconazole prophylaxis for the colonization and mortality of invasive candidiasis (IC) is unknown | ||
| 520 | |a PURPOSE: This systematic review and meta-analysis aimed to assess the efficiency of different prophylactic fluconazole schedules in controlling IC colonization, infection, and mortality in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants in neonatal intensive care units | ||
| 520 | |a METHODS: We searched the PubMed, Scopus, Embase, and Cochrane databases using the keywords "candida," "invasive candidiasis," "IC," "fluconazole prophylaxis," "preterm infants," "very low birth weight infants," "VLBW," "extremely low birth weight," and "ELBW." | ||
| 520 | |a RESULTS: Mortality was significantly decreased in a metaanalysis of studies using different fluconazole prophylaxis regimens. The meta-analysis also indicated a significant decrease in the incidence of IC-associated mortality in ELBW infants using the same fluconazole prophylaxis schedules | ||
| 520 | |a CONCLUSION: Future studies should explore the effectiveness of other different fluconazole prophylaxis schedules on IC colonization, infection, and mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Extremely low birth weight | |
| 650 | 4 | |a Fluconazole | |
| 650 | 4 | |a Invasive candidiasis | |
| 650 | 4 | |a Preterm infants | |
| 650 | 4 | |a Very low birth weight | |
| 700 | 1 | |a Nouri-Vaskeh, Masoud |e verfasserin |4 aut | |
| 700 | 1 | |a Abdoli Oskoei, Shahram |e verfasserin |4 aut | |
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