Early-life stress affects behavioral and neurochemical parameters differently in male and female juvenile Wistar rats

© 2020 International Society for Developmental Neuroscience..

Neonatal handling is an early life stressor that leads to behavioral and neurochemical changes in adult rats in a sex-specific manner and possibly affects earlier stages of development. Here, we investigated the effects of neonatal handling (days 1-10 after birth) on juvenile rats focusing on biochemical parameters and olfactory memory after weaning. Male neonatal handled rats performed more crossings on the hole-board task, increased Na+ /K+ -ATPase activity in the olfactory bulb, and decreased acetylcholinesterase activity in the hippocampus versus non-handled males. Female neonatal handled animals increased the number of rearing and nose-pokes on the hole-board task, decreased glutathione peroxidase activity, and total thiol content in the hippocampus versus non-handled females. This study reinforces that early life stress affects behavioral and neurochemical parameters in a sex-specific manner even before the puberty onset.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:80

Enthalten in:

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 80(2020), 6 vom: 30. Okt., Seite 547-557

Sprache:

Englisch

Beteiligte Personen:

Noschang, C [VerfasserIn]
Krolow, R [VerfasserIn]
Arcego, D M [VerfasserIn]
Marcolin, M [VerfasserIn]
Ferreira, A G [VerfasserIn]
da Cunha, A A [VerfasserIn]
Wyse, A T S [VerfasserIn]
Dalmaz, C [VerfasserIn]

Links:

Volltext

Themen:

Acetylcholinesterase
Behavior
Catalase
EC 1.11.1.6
EC 1.15.1.1
EC 3.1.1.7
EC 7.2.2.13
Journal Article
Juvenile
Neonatal handling
Neurochemistry
Sex differences
Sodium-Potassium-Exchanging ATPase
Superoxide Dismutase

Anmerkungen:

Date Completed 12.08.2021

Date Revised 12.08.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/jdn.10050

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31260033X