Salivary exosomes : properties, medical applications, and isolation methods

Salivary exosomes are extracellular vesicles (EVs) with abundant CD63 immunoreactivity on their surface. Based on their size and protein composition, these exosomes can be categorized into two classes of exosomes I (mean diameter of 83.5 nm) and II (mean diameter of 40.5 nm). We have attempted to review the features of these exosomes, including origin, composition, separation methods, and their application in medicine. Not only the composition of salivary exosomes is invaluable in term of diagnosis, but can also afford an understanding in roles of the contents and components of these exosomes in the fundamental pathophysiologic processes of different diseases. since these EVs can cross the epithelial barriers they may be essential for transporting of multifarious components from the blood into saliva. Thus, in comparison to other bodily fluids, salivary exosomes are probably a better and accessible tool to examine the function of exosomes in the diagnosis and treatment of disease.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:47

Enthalten in:

Molecular biology reports - 47(2020), 8 vom: 16. Aug., Seite 6295-6307

Sprache:

Englisch

Beteiligte Personen:

Cheshmi, Behzad [VerfasserIn]
Cheshomi, Hamid [VerfasserIn]

Links:

Volltext

Themen:

Biomarker
Biomarkers
Exosome
Extracellular vesicles
Journal Article
Review
Saliva
Salivary exosome
Tetraspanin 30

Anmerkungen:

Date Completed 26.05.2021

Date Revised 15.06.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s11033-020-05659-1

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312531796