Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved..
Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside in virtually all tissues, and the gain of MSCs by transplantation has become the leading form of cell therapy in various diseases. However, there is limited knowledge on the alteration of its efficacy by factors in recipients. Here, we report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor. The injected MSCs exert their function through exosomes, extracellular vesicles of endosome origin. Adiponectin stimulated exosome biogenesis and secretion through binding to T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin, on MSCs. A pharmacological or adenovirus-mediated genetic increase in plasma adiponectin enhanced the therapeutic efficacy of MSCs. Our findings provide novel insights into the importance of adiponectin in mesenchymal-progenitor-mediated organ protections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Molecular therapy : the journal of the American Society of Gene Therapy - 28(2020), 10 vom: 07. Okt., Seite 2203-2219 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nakamura, Yuto [VerfasserIn] |
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| Links: |
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| Themen: |
Adiponectin |
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| Anmerkungen: |
Date Completed 11.08.2021 Date Revised 11.08.2021 published: Print-Electronic Dryad: 10.5061/dryad.t76hdr7xq Citation Status MEDLINE |
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| doi: |
10.1016/j.ymthe.2020.06.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312287607 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Mesenchymal stem/stromal cells (MSCs) are cultured adult stem cells that originally reside in virtually all tissues, and the gain of MSCs by transplantation has become the leading form of cell therapy in various diseases. However, there is limited knowledge on the alteration of its efficacy by factors in recipients. Here, we report that the cardioprotective properties of intravenously injected MSCs in a mouse model of pressure-overload heart failure largely depend on circulating adiponectin, an adipocyte-secreted factor. The injected MSCs exert their function through exosomes, extracellular vesicles of endosome origin. Adiponectin stimulated exosome biogenesis and secretion through binding to T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin, on MSCs. A pharmacological or adenovirus-mediated genetic increase in plasma adiponectin enhanced the therapeutic efficacy of MSCs. Our findings provide novel insights into the importance of adiponectin in mesenchymal-progenitor-mediated organ protections | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Kita, Shunbun |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Yoshimitsu |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuda, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Obata, Yoshinari |e verfasserin |4 aut | |
| 700 | 1 | |a Okita, Tomonori |e verfasserin |4 aut | |
| 700 | 1 | |a Nishida, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawachi, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugawa-Shimizu, Yuri |e verfasserin |4 aut | |
| 700 | 1 | |a Fujishima, Yuya |e verfasserin |4 aut | |
| 700 | 1 | |a Nishizawa, Hitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Takakura, Yoshinobu |e verfasserin |4 aut | |
| 700 | 1 | |a Miyagawa, Shigeru |e verfasserin |4 aut | |
| 700 | 1 | |a Sawa, Yoshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Maeda, Norikazu |e verfasserin |4 aut | |
| 700 | 1 | |a Shimomura, Iichiro |e verfasserin |4 aut | |
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