Lactobacillus plantarum LP33 attenuates Pb-induced hepatic injury in rats by reducing oxidative stress and inflammation and promoting Pb excretion
Copyright © 2020 Elsevier Ltd. All rights reserved..
Lead (Pb) is one of the most common heavy metals and is harmful to human health. The liver is considered as a major target organ for Pb poisoning. Although probiotics have been shown to alleviate liver injury, the protective effect of Lactobacillus plantarum LP33 (LP33) against Pb-induced hepatotoxicity remains unclear. In order to explore the hepatoprotective effect of LP33, LP33 was administered to Pb-intoxicated Sprague-Dawley rats once daily by oral gavage for 8 weeks. The present results showed that LP33 supplementation alleviated liver injury, and inhibited oxidative stress and inflammation in Pb-exposed rats. Treatment with LP33 also promoted the phosphorylation of adenosine monophosphate-activated protein kinase and protein kinase B, activated nuclear factor erythroid 2-related factor 2 signaling and inhibited the activation of nuclear factor-κB signaling in liver tissues of rats exposed to Pb. Additionally, LP33 exhibited adequate Pb-binding capacity and satisfactory survival under simulated gastrointestinal conditions in vitro, and promoted Pb excretion via enterohepatic circulation of bile acids. This study demonstrated that LP33 reduced Pb-induced oxidative stress and inflammation and promoted Pb excretion, thereby attenuating the Pb-induced hepatic injury. Our findings suggest that LP33 supplementation may be a potential strategy for the treatment of Pb-induced hepatic toxicity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:143 |
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| Enthalten in: |
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 143(2020) vom: 10. Sept., Seite 111533 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Ting [VerfasserIn] |
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| Links: |
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| Themen: |
2P299V784P |
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| Anmerkungen: |
Date Completed 22.04.2021 Date Revised 22.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fct.2020.111533 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312222653 |
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| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Lead (Pb) is one of the most common heavy metals and is harmful to human health. The liver is considered as a major target organ for Pb poisoning. Although probiotics have been shown to alleviate liver injury, the protective effect of Lactobacillus plantarum LP33 (LP33) against Pb-induced hepatotoxicity remains unclear. In order to explore the hepatoprotective effect of LP33, LP33 was administered to Pb-intoxicated Sprague-Dawley rats once daily by oral gavage for 8 weeks. The present results showed that LP33 supplementation alleviated liver injury, and inhibited oxidative stress and inflammation in Pb-exposed rats. Treatment with LP33 also promoted the phosphorylation of adenosine monophosphate-activated protein kinase and protein kinase B, activated nuclear factor erythroid 2-related factor 2 signaling and inhibited the activation of nuclear factor-κB signaling in liver tissues of rats exposed to Pb. Additionally, LP33 exhibited adequate Pb-binding capacity and satisfactory survival under simulated gastrointestinal conditions in vitro, and promoted Pb excretion via enterohepatic circulation of bile acids. This study demonstrated that LP33 reduced Pb-induced oxidative stress and inflammation and promoted Pb excretion, thereby attenuating the Pb-induced hepatic injury. Our findings suggest that LP33 supplementation may be a potential strategy for the treatment of Pb-induced hepatic toxicity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Lactobacillus plantarum | |
| 650 | 4 | |a Liver injury | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Pb excretion | |
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| 650 | 7 | |a Lead |2 NLM | |
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| 700 | 1 | |a Li, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hongwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Suo, Huayi |e verfasserin |4 aut | |
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