Determination of behavior of catalpol hexapropionate in simulated gastric conditions by UPLC-ESI-HRMS

Catalpol hexapropionate (CP-6) was designed and synthesized as anti-aging drug. In order to investigate the behavior of CP-6 in simulated gastric juice, ultra-high performance liquid chromatography-electrospray ionization-high resolution mass spectrometry was used to determinate the components produced in simulated gastric conditions. Six metabolites were identified with the possible metabolic processes proposed. Hydrolysis may be the main metabolic pathways. The relative contents of CP-6 and its metabolites were determined using their extractive ion chromatograms. The results show that the relative content of CP-6 is rapidly decreased about 15% during the first 0.5 h and generally stable after 0.5 h. The mainly produced metabolites are catalpol penta-propionate (CP-5), catalpol and a spot of catalpol tetra-propionate (CP-4), catalpol tri-propionate (CP-3), catalpol dipropionate (CP-2) and catalpol propionate (CP-1). The metabolitic process of CP-6 may be an hydrolysis under acid conditions. The research results can provide useful information for development and utilization of CP-6 as a pharmaceutical preparation.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:10

Enthalten in:

Scientific reports - 10(2020), 1 vom: 07. Juli, Seite 11185

Sprache:

Englisch

Beteiligte Personen:

Cheng, Xiaodong [VerfasserIn]
Zhang, Qiuxia [VerfasserIn]
Li, Zhenxing [VerfasserIn]
Dong, Chunhong [VerfasserIn]
Jiang, Shiqing [VerfasserIn]
Sun, Yu-An [VerfasserIn]
Wang, Guoqing [VerfasserIn]

Links:

Volltext

Themen:

2415-24-9
Catalpol
Iridoid Glucosides
Journal Article
Propionates
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 10.12.2020

Date Revised 11.11.2023

published: Electronic

Citation Status MEDLINE

doi:

10.1038/s41598-020-68056-5

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312138164