Morusalisins A-F, six new Diels-Alder type adducts, as potential PTP1B inhibitors from cell cultures of Morus alba
Copyright © 2020. Published by Elsevier B.V..
Six new Diels-Alder type adducts, morusalisins A-F (1-6), were isolated from Morus alba cell cultures. The structures of 1-6 were determined by extensive spectroscopic data analysis, including HRESIMS, NMR, and ECD experiments. Furthermore, compounds 1-6 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 1.14 to 2.24 μM, making them promising as bioactive compounds for anti-diabetic drug discovery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:146 |
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| Enthalten in: |
Fitoterapia - 146(2020) vom: 20. Okt., Seite 104682 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Su, Cong [VerfasserIn] |
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| Links: |
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| Themen: |
Diels-Alder adducts |
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| Anmerkungen: |
Date Completed 15.03.2021 Date Revised 15.03.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2020.104682 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312066597 |
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| 520 | |a Six new Diels-Alder type adducts, morusalisins A-F (1-6), were isolated from Morus alba cell cultures. The structures of 1-6 were determined by extensive spectroscopic data analysis, including HRESIMS, NMR, and ECD experiments. Furthermore, compounds 1-6 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 1.14 to 2.24 μM, making them promising as bioactive compounds for anti-diabetic drug discovery | ||
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| 700 | 1 | |a Tian, Jinying |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jimei |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Kebo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Dawei |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ridao |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Jungui |e verfasserin |4 aut | |
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