A new lignan glucoside from root of Paeonia lactiflora
A new lignan glucoside,(+)-fragransin A_2-4-O-β-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 μmol·L~(-1).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica - 45(2020), 12 vom: 06. Juni, Seite 2903-2906 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Zhong, Wan-Chao [VerfasserIn] |
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| Links: |
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| Themen: |
Chemical constituents |
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| Anmerkungen: |
Date Completed 17.09.2020 Date Revised 17.09.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.19540/j.cnki.cjcmm.20200328.203 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM312051662 |
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| 520 | |a A new lignan glucoside,(+)-fragransin A_2-4-O-β-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 μmol·L~(-1) | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Xia, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Gui-Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jing-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Gui-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Sheng |e verfasserin |4 aut | |
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