Characterization of lncRNA-Perturbed TLR-Signaling Network Identifies Novel lncRNA Prognostic Biomarkers in Colorectal Cancer

Copyright © 2020 Chu, Liu, Liu, Yu, Zhang and Pei..

Increasing evidence has suggested that long non-coding RNAs (lncRNAs) are critical regulators in the Toll-like receptors (TLR)-signaling network to modulate colorectal cancer (CRC) development and progression. However, the mechanism and clinical significance for lncRNAs regulating TLR signaling pathways in CRC remained largely unknown. In this study, we performed an integrative network analysis of transcriptomics by focusing on a lncRNA-perturbed TLR-signaling network, identifying 280 lncRNAs and 122 mRNAs. We found a profound phenomenon that abnormal expression of some lncRNAs can perturb the TLR-signaling network to contribute to CRC development and progression. Furthermore, we identified a novel TLR-related prognostic gene signature (TLRLncSig) composed of three lncRNAs (MCHR2, AC011472.4, and AC063944.1), and one mRNA (CDKN2B). Utilizing TLRLncSig could classify CRC patients of training set into two groups with significantly different overall survival. The prognostic value of the TLRLncSig was further validated in the other two independent CRC datasets with different platforms. Results of multivariate and stratification analysis indicated that the TLRLncSig is an independent prognostic factor, and our study underscores the clinical significance of TLR-related lncRNAs in CRC development and progression.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:8

Enthalten in:

Frontiers in cell and developmental biology - 8(2020) vom: 01., Seite 503

Sprache:

Englisch

Beteiligte Personen:

Chu, Yanjie [VerfasserIn]
Liu, Zhiqiang [VerfasserIn]
Liu, Jing [VerfasserIn]
Yu, Lei [VerfasserIn]
Zhang, Dekai [VerfasserIn]
Pei, Fenghua [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers
CeRNA network
Colorectal cancer
Journal Article
Long non-coding RNAs
Toll-like receptors

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fcell.2020.00503

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM312044143