Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis
OBJECTIVES: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children.
METHODS: Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed.
RESULTS: Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA + AG vs. GG) the miR-SNP rs4284505 was associated with moderate DF, with carriers of the GG genotype having an increased risk of more than two times for DF (p = 0.031; Odds Ratio = 2.26, Confidence Interval 95%= 1.04-4.73). Allelic distribution showed borderline statistical significance for moderate DF with the carriers of G allele having an increased risk for DF (p = .050; Odds Ratio = 1.75, Confidence Interval 95%= 1.00-3.12).
CONCLUSION: The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
|---|---|
| Enthalten in: |
Acta odontologica Scandinavica - 78(2020), 6 vom: 29. Aug., Seite 463-466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abbasoglu, Zerrin [VerfasserIn] |
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| Links: |
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| Themen: |
Dental fluorosis |
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| Anmerkungen: |
Date Completed 21.08.2020 Date Revised 21.08.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00016357.2020.1786600 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31197094X |
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| 245 | 1 | 0 | |a Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 21.08.2020 | ||
| 500 | |a Date Revised 21.08.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children | ||
| 520 | |a METHODS: Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed | ||
| 520 | |a RESULTS: Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA + AG vs. GG) the miR-SNP rs4284505 was associated with moderate DF, with carriers of the GG genotype having an increased risk of more than two times for DF (p = 0.031; Odds Ratio = 2.26, Confidence Interval 95%= 1.04-4.73). Allelic distribution showed borderline statistical significance for moderate DF with the carriers of G allele having an increased risk for DF (p = .050; Odds Ratio = 1.75, Confidence Interval 95%= 1.00-3.12) | ||
| 520 | |a CONCLUSION: The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF | ||
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| 700 | 1 | |a Wambier, Letícia M |e verfasserin |4 aut | |
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| 700 | 1 | |a Andrades, Kesly Mary R |e verfasserin |4 aut | |
| 700 | 1 | |a Scariot, Rafaela |e verfasserin |4 aut | |
| 700 | 1 | |a Trevilatto, Paula C |e verfasserin |4 aut | |
| 700 | 1 | |a Brancher, João A |e verfasserin |4 aut | |
| 700 | 1 | |a Küchler, Erika C |e verfasserin |4 aut | |
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