Isolated Intracranial Myeloid Sarcoma Mimicking Malignant Lymphoma : A Diagnostic Challenge and Literature Reviews

© 2020 Xu et al..

Isolated intracranial myeloid sarcoma (MS) is an unusual variant tumor with few cases reported so far in the medical literature. A 29-year-old woman was admitted to our hospital presenting progressive visual loss in the right eye and weight loss (20 kg) without a previous history of hematological disease (HD). Radiologic evaluation showed the evidence of intracranial mass. Histologically, the resected tumor was composed of a uniform population of primitive cells and primarily misdiagnosed as a T-cell non-Hodgkin's lymphoma (NHL). Chemotherapy with cyclophosphamide, doxorubicin, vinblastine, and prednisone (CHOP) was ineffective. A biopsy and histopathological evaluation were repeated, and immunohistochemical staining revealed the positivity of immature cells to an extensive panel of myeloid markers. These findings were consistent with a diagnosis of MS and bone marrow infiltration. Literature reviews of previous cases were also undertaken.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

OncoTargets and therapy - 13(2020) vom: 15., Seite 6085-6092

Sprache:

Englisch

Beteiligte Personen:

Xu, Guixuan [VerfasserIn]
Zhang, Haijun [VerfasserIn]
Nong, Weixia [VerfasserIn]
Li, Chunsen [VerfasserIn]
Meng, Lian [VerfasserIn]
Liu, Chunxia [VerfasserIn]
Li, Feng [VerfasserIn]

Links:

Volltext

Themen:

Case Reports
Intracranial
Isolated
Misdiagnosis
Myeloid sarcoma
Non-Hodgkin’s lymphoma

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.2147/OTT.S245828

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311902162