Neuroprotective effects of the peel of Citrus kawachiensis (Kawachi Bankan) and auraptene in the hippocampus of hyperglycemia mice and global cerebral ischemia/reperfusion injury mice

The peel of Citrus kawachiensis (Kawachi Bankan), a citrus species grown in Ehime, Japan, is abundant in auraptene. Auraptene, a coumarin compound, have been shown to exert anti-inflammatory effects in peripheral tissues, but it was still unclear of the effect in the brain. Hyperglycemia and brain ischemia induce inflammation and oxidative stress and cause massive damage in the brain; therefore, we examined the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis and auraptene in a hyperglycemia and global cerebral ischemia models. The C. kawachiensis treatment inhibited astroglial activation in the hippocampus and the hyperphosphorylation of tau protein in hippocampal neurons, and also relieved the suppression of neurogenesis in the dentate gyrus of the hippocampus in the type 2 diabetic db/db mice. The C. kawachiensis treatment inhibited microglial and astroglial activation, and neuronal cell death in the hippocampus of transient global cerebral ischemia mice. It was suggested that the dried peel powder of C. kawachiensis exerts anti-inflammatory and neuroprotective effects in the brain. We attempted to demonstrate the effect of auraptene in the brains in streptozotocin-induced hyperglycemic mice and transient global cerebral ischemia mice. Auraptene administration showed the similar effects as the peel of C. kawachiensis in the hippocampus of these mice models. These results suggested that auraptene have potential effects as a neuroprotective agent in the peel of C. kawachiensis.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:155

Enthalten in:

Nihon yakurigaku zasshi. Folia pharmacologica Japonica - 155(2020), 4 vom: 01., Seite 214-219

Sprache:

Japanisch

Beteiligte Personen:

Okuyama, Satoshi [VerfasserIn]
Sawamoto, Atsushi [VerfasserIn]
Nakajima, Mitsunari [VerfasserIn]
Furukawa, Yoshiko [VerfasserIn]

Links:

Volltext

Themen:

Aurapten
Coumarins
F79I1ZEL2E
Journal Article
Neuroprotective Agents

Anmerkungen:

Date Completed 02.11.2020

Date Revised 02.11.2020

published: Print

Citation Status MEDLINE

doi:

10.1254/fpj.20022

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311898823