Zeb2 Is a Regulator of Astrogliosis and Functional Recovery after CNS Injury

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved..

The astrocytic response to injury is characterized on the cellular level, but our understanding of the molecular mechanisms controlling the cellular processes is incomplete. The astrocytic response to injury is similar to wound-healing responses in non-neural tissues that involve epithelial-to-mesenchymal transitions (EMTs) and upregulation in ZEB transcription factors. Here we show that injury-induced astrogliosis increases EMT-related genes expression, including Zeb2, and long non-coding RNAs, including Zeb2os, which facilitates ZEB2 protein translation. In mouse models of either contusive spinal cord injury or transient ischemic stroke, the conditional knockout of Zeb2 in astrocytes attenuates astrogliosis, generates larger lesions, and delays the recovery of motor function. These findings reveal ZEB2 as an important regulator of the astrocytic response to injury and suggest that astrogliosis is an EMT-like process, which provides a conceptual connection for the molecular and cellular similarities between astrogliosis and wound-healing responses in non-neural tissue.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

Cell reports - 31(2020), 13 vom: 30. Juni, Seite 107834

Sprache:

Englisch

Beteiligte Personen:

Vivinetto, Ana L [VerfasserIn]
Kim, Il-Doo [VerfasserIn]
Goldberg, David C [VerfasserIn]
Fones, Lilah [VerfasserIn]
Brown, Elizabeth [VerfasserIn]
Tarabykin, Victor S [VerfasserIn]
Hill, Caitlin E [VerfasserIn]
Cho, Sunghee [VerfasserIn]
Cave, John W [VerfasserIn]

Links:

Volltext

Themen:

Astrocytes
Epithelial-to-mesenchymal transition
Journal Article
Long non-coding RNA
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Spinal cord injury
Stroke
Wound healing
Zinc Finger E-box Binding Homeobox 2

Anmerkungen:

Date Completed 28.04.2021

Date Revised 28.04.2021

published: Print

Citation Status MEDLINE

doi:

10.1016/j.celrep.2020.107834

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311880002