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High-dose, short-term corticosteroids for ARDS caused by COVID-19 : a case series

© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.

We report a case series of seven mechanically ventilated patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease (COVID-19) who received early treatment with high-dose, short-term systemic corticosteroids to prevent cytokine overproduction. Of the seven patients, four were male and median age was 69 years. They were intubated within seven days after admission when their respiratory status rapidly worsened. At that time, we administered 1000 or 500 mg/day for three days of methylprednisolone intravenously, followed by 1 mg/kg and tapered off. The median duration for the total administration of corticosteroids was 13 days. This high-dose, short-term corticosteroid therapy enabled extubation of the patients within seven days. Many questions on the clinical management of COVID-19 remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. We present the clinical course of our cases, review the previous evidence, and discuss management

Year of Publication: 2020
Contained in: Respirology case reports Vol. 8, No. 6 (2020), p. e00596
All journal articles: Search for all articles in this journal
Language: English
Contributors: So, Clara | Author
Ro, Shosei
Murakami, Manabu
Imai, Ryosuke
Jinta, Torahiko
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: ARDS
COVID‐19
Case Reports
corticosteroid therapy
mechanical ventilation
ISSN: 2051-3380
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Revised 19.06.2020
published: Electronic-eCollection
Citation Status PubMed-not-MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PMID:
    32514354
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1002/rcr2.596
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