Closable Valves and Channels for Polymeric Microfluidic Devices

This study explores three unique approaches for closing valves and channels within microfluidic systems, specifically multilayer, centrifugally driven polymeric devices. Precise control over the cessation of liquid movement is achieved through either the introduction of expanding polyurethane foam, the application of direct contact heating, or the redeposition of xerographic toner via chloroform solvation and evaporation. Each of these techniques modifies the substrate of the microdevice in a different way. All three are effective at closing a previously open fluidic pathway after a desired unit operation has taken place, i.e., sample metering, chemical reaction, or analytical measurement. Closing previously open valves and channels imparts stringent fluidic control-preventing backflow, maintaining pressurized chambers within the microdevice, and facilitating sample fractionation without cross-contamination. As such, a variety of microfluidic bioanalytical systems would benefit from the integration of these valving approaches.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

Micromachines - 11(2020), 7 vom: 27. Juni

Sprache:

Englisch

Beteiligte Personen:

Clark, Charles P [VerfasserIn]
Woolf, M Shane [VerfasserIn]
Karstens, Sarah L [VerfasserIn]
Lewis, Hannah M [VerfasserIn]
Nauman, Aeren Q [VerfasserIn]
Landers, James P [VerfasserIn]

Links:

Volltext

Themen:

Centrifugal
Closable valving
Contact heating
Expandable foam
Journal Article
Microfluidic
Redeposition

Anmerkungen:

Date Revised 28.09.2020

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/mi11070627

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311830668