Closable Valves and Channels for Polymeric Microfluidic Devices
This study explores three unique approaches for closing valves and channels within microfluidic systems, specifically multilayer, centrifugally driven polymeric devices. Precise control over the cessation of liquid movement is achieved through either the introduction of expanding polyurethane foam, the application of direct contact heating, or the redeposition of xerographic toner via chloroform solvation and evaporation. Each of these techniques modifies the substrate of the microdevice in a different way. All three are effective at closing a previously open fluidic pathway after a desired unit operation has taken place, i.e., sample metering, chemical reaction, or analytical measurement. Closing previously open valves and channels imparts stringent fluidic control-preventing backflow, maintaining pressurized chambers within the microdevice, and facilitating sample fractionation without cross-contamination. As such, a variety of microfluidic bioanalytical systems would benefit from the integration of these valving approaches.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
---|---|
Enthalten in: |
Micromachines - 11(2020), 7 vom: 27. Juni |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Clark, Charles P [VerfasserIn] |
---|
Links: |
---|
Themen: |
Centrifugal |
---|
Anmerkungen: |
Date Revised 28.09.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3390/mi11070627 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM311830668 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM311830668 | ||
003 | DE-627 | ||
005 | 20231225143110.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3390/mi11070627 |2 doi | |
028 | 5 | 2 | |a pubmed24n1039.xml |
035 | |a (DE-627)NLM311830668 | ||
035 | |a (NLM)32605093 | ||
035 | |a (PII)E627 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Clark, Charles P |e verfasserin |4 aut | |
245 | 1 | 0 | |a Closable Valves and Channels for Polymeric Microfluidic Devices |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 28.09.2020 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a This study explores three unique approaches for closing valves and channels within microfluidic systems, specifically multilayer, centrifugally driven polymeric devices. Precise control over the cessation of liquid movement is achieved through either the introduction of expanding polyurethane foam, the application of direct contact heating, or the redeposition of xerographic toner via chloroform solvation and evaporation. Each of these techniques modifies the substrate of the microdevice in a different way. All three are effective at closing a previously open fluidic pathway after a desired unit operation has taken place, i.e., sample metering, chemical reaction, or analytical measurement. Closing previously open valves and channels imparts stringent fluidic control-preventing backflow, maintaining pressurized chambers within the microdevice, and facilitating sample fractionation without cross-contamination. As such, a variety of microfluidic bioanalytical systems would benefit from the integration of these valving approaches | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a centrifugal | |
650 | 4 | |a closable valving | |
650 | 4 | |a contact heating | |
650 | 4 | |a expandable foam | |
650 | 4 | |a microfluidic | |
650 | 4 | |a redeposition | |
700 | 1 | |a Woolf, M Shane |e verfasserin |4 aut | |
700 | 1 | |a Karstens, Sarah L |e verfasserin |4 aut | |
700 | 1 | |a Lewis, Hannah M |e verfasserin |4 aut | |
700 | 1 | |a Nauman, Aeren Q |e verfasserin |4 aut | |
700 | 1 | |a Landers, James P |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Micromachines |d 2013 |g 11(2020), 7 vom: 27. Juni |w (DE-627)NLM243194161 |x 2072-666X |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2020 |g number:7 |g day:27 |g month:06 |
856 | 4 | 0 | |u http://dx.doi.org/10.3390/mi11070627 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 11 |j 2020 |e 7 |b 27 |c 06 |