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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. We enrolled 102 COVID-19 patients who were admitted to Renmin Hospital (Wuhan, China). All patients were classified into moderate, severe and critical groups according to their symptoms. 45 control samples of healthy volunteers were also included. Inflammatory cytokines and C-Reactive Protein (CRP) profiles of serum samples were analyzed by specific immunoassays. Results showed that COVID-19 patients have higher serum level of cytokines (TNF-α, IFN-γ, IL-2, IL-4, IL-6 and IL-10) and CRP than control individuals. Within COVID-19 patients, serum IL-6 and IL-10 levels are significantly higher in critical group (n = 17) than in moderate (n = 42) and severe (n = 43) group. The levels of IL-10 is positively correlated with CRP amount (r = 0.41, P < 0.01). Using univariate logistic regression analysis, IL-6 and IL-10 are found to be predictive of disease severity and receiver operating curve analysis could further confirm this result (AUC = 0.841, 0.822 respectively). Our result indicated higher levels of cytokine storm is associated with more severe disease development. Among them, IL-6 and IL-10 can be used as predictors for fast diagnosis of patients with higher risk of disease deterioration. Given the high levels of cytokines induced by SARS-CoV-2, treatment to reduce inflammation-related lung damage is critical

Year of Publication: 2020
Contained in: Emerging microbes & infections Vol. 9, No. 1 (2020), p. 1123-1130
All journal articles: Search for all articles in this journal
Language: English
Contributors: Han, Huan | Author
Ma, Qingfeng
Li, Cong
Liu, Rui
Zhao, Li
Wang, Wei
Zhang, Pingan
Liu, Xinghui
Gao, Guosheng
Liu, Fang
Jiang, Yingan
Cheng, Xiaoming
Zhu, Chengliang
Xia, Yuchen
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: 130068-27-8
9007-41-4
COVID-19
IL10 protein, human
IL6 protein, human
Interleukin 10
Interleukin 6
Journal Article
SARS-CoV-2
cytokine storm
inflammatory cytokines
Additional Keywords: Betacoronavirus
Biomarkers
C-Reactive Protein
China
Coronavirus Infections
Critical Illness
Cytokine Release Syndrome
Cytokines
Humans
Interleukin-10
Interleukin-6
Pandemics
Pneumonia, Viral
ISSN: 2222-1751
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Completed 02.06.2020
Date Revised 02.06.2020
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PMID:
    32475230
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1080/22221751.2020.1770129
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