Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation
Copyright © 2020 Elsevier Ltd. All rights reserved..
Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:255 |
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Enthalten in: |
Biomaterials - 255(2020) vom: 10. Okt., Seite 120197 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Bai, Jiaxiang [VerfasserIn] |
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Links: |
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Themen: |
Biomimetic peptide |
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Anmerkungen: |
Date Completed 14.05.2021 Date Revised 14.05.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.biomaterials.2020.120197 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM311425755 |
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520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
520 | |a Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Biomimetic peptide | |
650 | 4 | |a Chronic inflammation | |
650 | 4 | |a Osseointegration | |
650 | 4 | |a Osteoimmunomodulatory | |
650 | 4 | |a Ti implants | |
650 | 7 | |a Coated Materials, Biocompatible |2 NLM | |
650 | 7 | |a Peptides |2 NLM | |
650 | 7 | |a Titanium |2 NLM | |
650 | 7 | |a D1JT611TNE |2 NLM | |
700 | 1 | |a Wang, Huaiyu |e verfasserin |4 aut | |
700 | 1 | |a Chen, Hao |e verfasserin |4 aut | |
700 | 1 | |a Ge, Gaoran |e verfasserin |4 aut | |
700 | 1 | |a Wang, Miao |e verfasserin |4 aut | |
700 | 1 | |a Gao, Ang |e verfasserin |4 aut | |
700 | 1 | |a Tong, Liping |e verfasserin |4 aut | |
700 | 1 | |a Xu, Yaozeng |e verfasserin |4 aut | |
700 | 1 | |a Yang, Huiling |e verfasserin |4 aut | |
700 | 1 | |a Pan, Guoqing |e verfasserin |4 aut | |
700 | 1 | |a Chu, Paul K |e verfasserin |4 aut | |
700 | 1 | |a Geng, Dechun |e verfasserin |4 aut | |
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