Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation

Copyright © 2020 Elsevier Ltd. All rights reserved..

Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. In addition, the peptide coating increases the bone-implant contact (BIC) by nearly 3 times resulting in suppressed osteoclastogenesis and promoted osteogenesis by inhibiting the nuclear factor kappa-B (NF-κB) signalling pathway. Our findings indicate that biomimetic peptides with osteoimmunomodulatory bioactivity can be incorporated into Ti-based prostheses to facilitate bone regeneration in patients with chronic inflammatory diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:255

Enthalten in:

Biomaterials - 255(2020) vom: 10. Okt., Seite 120197

Sprache:

Englisch

Beteiligte Personen:

Bai, Jiaxiang [VerfasserIn]
Wang, Huaiyu [VerfasserIn]
Chen, Hao [VerfasserIn]
Ge, Gaoran [VerfasserIn]
Wang, Miao [VerfasserIn]
Gao, Ang [VerfasserIn]
Tong, Liping [VerfasserIn]
Xu, Yaozeng [VerfasserIn]
Yang, Huiling [VerfasserIn]
Pan, Guoqing [VerfasserIn]
Chu, Paul K [VerfasserIn]
Geng, Dechun [VerfasserIn]

Links:

Volltext

Themen:

Biomimetic peptide
Chronic inflammation
Coated Materials, Biocompatible
D1JT611TNE
Journal Article
Osseointegration
Osteoimmunomodulatory
Peptides
Research Support, Non-U.S. Gov't
Ti implants
Titanium

Anmerkungen:

Date Completed 14.05.2021

Date Revised 14.05.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.biomaterials.2020.120197

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311425755