Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: COVID-19 is a potentially severe disease caused by the recently described SARS-CoV-2. Whether liver fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown. We aimed to evaluate the association between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19.
METHODS: In this multicenter, retrospective study with prospective follow-up of 160 patients aged 35-65 years with COVID-19, FIB-4, clinical, and biochemical variables were collected at baseline. FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis.
RESULTS: Risk for advanced fibrosis was estimated in 28.1% of patients. Patients with FIB-4 ≥2.67 more frequently required mechanical ventilation (37.8% vs 18.3%; P = .009). In multivariate analysis, FIB-4 ≥2.67 (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.30-8.92), cardiovascular risk factors (OR, 5.05; 95% CI, 1.90-13.39), previous respiratory diseases (OR, 4.54; 95% CI, 1.36-15.10), and C-reactive protein (OR, 1.01; 95% CI, 1.01-1.02) increased significantly the risk of ICU admission. Bootstrap confirmed FIB-4 as an independent risk factor.
CONCLUSIONS: In middle-aged patients with COVID-19, FIB-4 may have a prognostic role. The link between liver fibrosis and the natural history of COVID-19 should be evaluated in future studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:222 |
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| Enthalten in: |
The Journal of infectious diseases - 222(2020), 5 vom: 04. Aug., Seite 726-733 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ibáñez-Samaniego, Luis [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 12.08.2020 Date Revised 11.05.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiaa355 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311418279 |
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| 245 | 1 | 0 | |a Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19 |
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| 520 | |a © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: COVID-19 is a potentially severe disease caused by the recently described SARS-CoV-2. Whether liver fibrosis might be a relevant player in the natural history of COVID-19 is currently unknown. We aimed to evaluate the association between FIB-4 and the risk of progression to critical illness in middle-aged patients with COVID-19 | ||
| 520 | |a METHODS: In this multicenter, retrospective study with prospective follow-up of 160 patients aged 35-65 years with COVID-19, FIB-4, clinical, and biochemical variables were collected at baseline. FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis | ||
| 520 | |a RESULTS: Risk for advanced fibrosis was estimated in 28.1% of patients. Patients with FIB-4 ≥2.67 more frequently required mechanical ventilation (37.8% vs 18.3%; P = .009). In multivariate analysis, FIB-4 ≥2.67 (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.30-8.92), cardiovascular risk factors (OR, 5.05; 95% CI, 1.90-13.39), previous respiratory diseases (OR, 4.54; 95% CI, 1.36-15.10), and C-reactive protein (OR, 1.01; 95% CI, 1.01-1.02) increased significantly the risk of ICU admission. Bootstrap confirmed FIB-4 as an independent risk factor | ||
| 520 | |a CONCLUSIONS: In middle-aged patients with COVID-19, FIB-4 may have a prognostic role. The link between liver fibrosis and the natural history of COVID-19 should be evaluated in future studies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a FIB-4 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a critical illness | |
| 650 | 4 | |a liver fibrosis | |
| 700 | 1 | |a Bighelli, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Usón, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Caravaca, Celia |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández Carrillo, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Romero, Miriam |e verfasserin |4 aut | |
| 700 | 1 | |a Barreales, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Perelló, Christie |e verfasserin |4 aut | |
| 700 | 1 | |a Madejón, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Marcos, Aránzazu Caballero |e verfasserin |4 aut | |
| 700 | 1 | |a Albillos, Agustín |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, Inmaculada |e verfasserin |4 aut | |
| 700 | 1 | |a García-Samaniego, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Calleja, José Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Bañares, Rafael |e verfasserin |4 aut | |
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