Fabry disease during the COVID-19 pandemic. Why and how treatment should be continued

Copyright © 2020 Elsevier Inc. All rights reserved..

Fabry disease is an X-linked disease due to a deficiency of the lysosomal enzyme alpha-galactosidase A. Clinical symptoms in classically affected males include acroparesthesia, anhydrosis and angiokeratoma, which may present during childhood followed by cardiac, cerebral and renal complications. Even though pulmonary involvement is not widely appreciated by clinicians, an obstructive lung disease is another recognized component of Fabry disease. Coronavirus Disease-19 (COVID-19), caused by the SARS-CoV-2 virus was labeled as a global pandemic and patients with Fabry disease can be considered at high risk of developing severe complications. The impact of COVID-19 on patients with Fabry disease receiving enzyme replacement therapy is still unknown. Many patients who receive treatment in the hospital experienced infusion disruptions due to fear of infection. Effects of temporary treatment interruption was described in more detail in other lysosomal storage diseases, but the recommencement of therapy does not fully reverse clinical decline due to the temporary discontinuation. When possible, home-therapy seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic. Sentence take-home message: Home-therapy, when possible, seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic in patients with Fabry disease.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:130

Enthalten in:

Molecular genetics and metabolism - 130(2020), 4 vom: 20. Aug., Seite 227-229

Sprache:

Englisch

Beteiligte Personen:

Politei, Juan [VerfasserIn]

Links:

Volltext

Themen:

2HLC17MX9G
Agalsidase alfa
Agalsidase beta
Alpha-Galactosidase
Covid-19
EC 3.2.1.22
Enzyme replacement therapy
Fabry disease
Isoenzymes
Journal Article
Pulmonary involvement
RZD65TSM9U
Recombinant Proteins

Anmerkungen:

Date Completed 20.07.2020

Date Revised 10.01.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.ymgme.2020.06.002

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311400159