Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice
Copyright © 2020 Elsevier Ltd. All rights reserved..
The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:161 |
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| Enthalten in: |
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine - 161(2020) vom: 14. Juli, Seite 109162 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lo, Wei-Lin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.07.2021 Date Revised 07.07.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.apradiso.2020.109162 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Chen, Liang-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Shih-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Lo, Sheng-Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ming-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ruei-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, I-Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Han-Chung |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Chih-Hsien |e verfasserin |4 aut | |
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