Clinical profile and 1-year clinical outcomes of super elderly patients admitted with acute heart failure
Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved..
INTRODUCTION: There is scarce information about the clinical profile and prognosis of acute heart failure (AHF) at the extreme ranges of age. We aimed to evaluate the 1-year death (all-cause mortality and HF-death) and HF-rehospitalizations of patients ≥85 years admitted for AHF.
METHODS: We prospectively evaluated a cohort of 3054 patients admitted with AHF from 2007 to 2018 in a third-level center. Age was categorized per 10-year categories (<65 years; 65-74 years, 75-84 years, and ≥85 years). The risk of mortality and HF-rehospitalizations across age categories was evaluated with Cox regression analysis and Cox regression adapted for competing events as appropriate.
RESULTS: The mean age was 73.6 ± 11.2 years, 48.9% were female, and 52.8% had preserved left ventricular ejection fraction (HFpEF). A total of 414 (13.6%) patients were ≥85 years. Among this group of age, female sex and HFpEF phenotype were more frequent. At 1-year follow-up 667 all-cause deaths (22,1%), 311 HF-deaths (10.1%) and 693 HF-hospitalizations (22,7%) were recorded. After multivariable adjustment, and compared to patients <65 years, a stepwise increased risk of all-cause mortality and HF-death was found for each decade increase in age, especially for patients ≥85 years (HR=3.47; 95% CI: 2.49 - 4.84, p<0.001, HR=3.31; 95% CI: 1.95 - 5.63; p<0.001, respectively). This subgroup of patients also showed an increased risk of HF-rehospitalization (HR=1.58; 95% CI: 1.16 - 2.16, p=0.004).
CONCLUSIONS: Super elderly patients admitted with AHF showed a dramatically increased risk of 1-year death. This subset of patients also shown an increased risk of 1-year HF-readmission.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
European journal of internal medicine - 81(2020) vom: 15. Nov., Seite 78-82 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lorenzo, Miguel [VerfasserIn] |
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| Links: |
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| Themen: |
Acute heart failure |
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| Anmerkungen: |
Date Completed 15.02.2021 Date Revised 15.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejim.2020.05.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311323405 |
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| 100 | 1 | |a Lorenzo, Miguel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical profile and 1-year clinical outcomes of super elderly patients admitted with acute heart failure |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 15.02.2021 | ||
| 500 | |a Date Revised 15.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a INTRODUCTION: There is scarce information about the clinical profile and prognosis of acute heart failure (AHF) at the extreme ranges of age. We aimed to evaluate the 1-year death (all-cause mortality and HF-death) and HF-rehospitalizations of patients ≥85 years admitted for AHF | ||
| 520 | |a METHODS: We prospectively evaluated a cohort of 3054 patients admitted with AHF from 2007 to 2018 in a third-level center. Age was categorized per 10-year categories (<65 years; 65-74 years, 75-84 years, and ≥85 years). The risk of mortality and HF-rehospitalizations across age categories was evaluated with Cox regression analysis and Cox regression adapted for competing events as appropriate | ||
| 520 | |a RESULTS: The mean age was 73.6 ± 11.2 years, 48.9% were female, and 52.8% had preserved left ventricular ejection fraction (HFpEF). A total of 414 (13.6%) patients were ≥85 years. Among this group of age, female sex and HFpEF phenotype were more frequent. At 1-year follow-up 667 all-cause deaths (22,1%), 311 HF-deaths (10.1%) and 693 HF-hospitalizations (22,7%) were recorded. After multivariable adjustment, and compared to patients <65 years, a stepwise increased risk of all-cause mortality and HF-death was found for each decade increase in age, especially for patients ≥85 years (HR=3.47; 95% CI: 2.49 - 4.84, p<0.001, HR=3.31; 95% CI: 1.95 - 5.63; p<0.001, respectively). This subgroup of patients also showed an increased risk of HF-rehospitalization (HR=1.58; 95% CI: 1.16 - 2.16, p=0.004) | ||
| 520 | |a CONCLUSIONS: Super elderly patients admitted with AHF showed a dramatically increased risk of 1-year death. This subset of patients also shown an increased risk of 1-year HF-readmission | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute heart failure | |
| 650 | 4 | |a All-cause mortality | |
| 650 | 4 | |a HF-mortality | |
| 650 | 4 | |a HF-rehospitalization | |
| 650 | 4 | |a Superelderly | |
| 700 | 1 | |a de la Espriella, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Miñana, Gema |e verfasserin |4 aut | |
| 700 | 1 | |a Núñez, Gonzalo |e verfasserin |4 aut | |
| 700 | 1 | |a Santas, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Núñez, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Heredia, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Mollar, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Civera, Jose |e verfasserin |4 aut | |
| 700 | 1 | |a Villaescusa, Amparo |e verfasserin |4 aut | |
| 700 | 1 | |a Sastre, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Conesa, Adriana |e verfasserin |4 aut | |
| 700 | 1 | |a Bonanad, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Bayés-Genís, Antoni |e verfasserin |4 aut | |
| 700 | 1 | |a Núñez, Julio |e verfasserin |4 aut | |
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