The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health
Copyright © 2020 Elsevier B.V. All rights reserved..
BACKGROUNDS: Alexithymia, difficulties in identifying and describing one's own feelings, is related to substantial clinical practice. Inspired by the links between serotonin functions and affective disorders, this study investigated associations of the serotonin receptor 2A (5-HT2A) gene with alexithymia and mental health.
METHODS: We differentiated subjects according to two functional polymorphisms (i.e., rs6311 and rs6313) of 5-HT2A gene and scored alexithymia and mental health of college students with the Toronto Alexithymia Scale (TAS-20) and the Symptom Check List-90 (SCL-90), respectively.
RESULTS: The analyses basing on sample 1 (N = 566) and sample 2 (N = 602) indicated that the G allele of rs6311 was related to higher score on the TAS-20 as compared to the AA genotype. The analysis with 467 individuals from sample 2 indicated that the rs6311 was associated with mental health, and this association was mediated by alexithymia.
LIMITATIONS: The potential confounding variables such as depression and anxiety were neglected in the analyses.
CONCLUSIONS: These findings demonstrate the contribution of the 5-HT2A to alexithymia, and highlight the link between alexithymia and mental health at genetic level.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:272 |
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| Enthalten in: |
Journal of affective disorders - 272(2020) vom: 01. Juli, Seite 277-282 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Xiaohan [VerfasserIn] |
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| Links: |
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| Themen: |
Alexithymia |
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| Anmerkungen: |
Date Completed 15.02.2021 Date Revised 15.02.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jad.2020.03.153 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM311321232 |
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| 100 | 1 | |a Li, Xiaohan |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The rs6311 of serotonin receptor 2A (5-HT2A) gene is associated with alexithymia and mental health |
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| 500 | |a Date Completed 15.02.2021 | ||
| 500 | |a Date Revised 15.02.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUNDS: Alexithymia, difficulties in identifying and describing one's own feelings, is related to substantial clinical practice. Inspired by the links between serotonin functions and affective disorders, this study investigated associations of the serotonin receptor 2A (5-HT2A) gene with alexithymia and mental health | ||
| 520 | |a METHODS: We differentiated subjects according to two functional polymorphisms (i.e., rs6311 and rs6313) of 5-HT2A gene and scored alexithymia and mental health of college students with the Toronto Alexithymia Scale (TAS-20) and the Symptom Check List-90 (SCL-90), respectively | ||
| 520 | |a RESULTS: The analyses basing on sample 1 (N = 566) and sample 2 (N = 602) indicated that the G allele of rs6311 was related to higher score on the TAS-20 as compared to the AA genotype. The analysis with 467 individuals from sample 2 indicated that the rs6311 was associated with mental health, and this association was mediated by alexithymia | ||
| 520 | |a LIMITATIONS: The potential confounding variables such as depression and anxiety were neglected in the analyses | ||
| 520 | |a CONCLUSIONS: These findings demonstrate the contribution of the 5-HT2A to alexithymia, and highlight the link between alexithymia and mental health at genetic level | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alexithymia | |
| 650 | 4 | |a Mental health | |
| 650 | 4 | |a Polymorphism | |
| 650 | 4 | |a Serotonin | |
| 650 | 7 | |a Receptor, Serotonin, 5-HT2A |2 NLM | |
| 700 | 1 | |a He, Linlin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jinting |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Wenxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Quanhe |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Pengpeng |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Mengfei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chunlan |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Pingyuan |e verfasserin |4 aut | |
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