Treatments Administered to the First 9152 Reported Cases of COVID-19 : A Systematic Review

The emergence of SARS-CoV-2/2019 novel coronavirus (COVID-19) has created a global pandemic with no approved treatments or vaccines. Many treatments have already been administered to COVID-19 patients but have not been systematically evaluated. We performed a systematic literature review to identify all treatments reported to be administered to COVID-19 patients and to assess time to clinically meaningful response for treatments with sufficient data. We searched PubMed, BioRxiv, MedRxiv, and ChinaXiv for articles reporting treatments for COVID-19 patients published between 1 December 2019 and 27 March 2020. Data were analyzed descriptively. Of the 2706 articles identified, 155 studies met the inclusion criteria, comprising 9152 patients. The cohort was 45.4% female and 98.3% hospitalized, and mean (SD) age was 44.4 years (SD 21.0). The most frequently administered drug classes were antivirals, antibiotics, and corticosteroids, and of the 115 reported drugs, the most frequently administered was combination lopinavir/ritonavir, which was associated with a time to clinically meaningful response (complete symptom resolution or hospital discharge) of 11.7 (1.09) days. There were insufficient data to compare across treatments. Many treatments have been administered to the first 9152 reported cases of COVID-19. These data serve as the basis for an open-source registry of all reported treatments given to COVID-19 patients at . Further work is needed to prioritize drugs for investigation in well-controlled clinical trials and treatment protocols.

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Electronic Article

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Infectious diseases and therapy - Vol. 9, No. 3 (2020), p. 435-449




Fajgenbaum, David C
Khor, Johnson S
Gorzewski, Alexander
Tamakloe, Mark-Avery
Powers, Victoria
Kakkis, Joseph J
Repasky, Mileva
Taylor, Anne
Beschloss, Alexander
Hernandez-Miyares, Laura
Go, Beatrice
Nimgaonkar, Vivek
McCarthy, Madison S
Kim, Casey J
Pai, Ruth-Anne Langan
Frankl, Sarah
Angelides, Philip
Jiang, Joanna
Rasheed, Rozena
Napier, Erin
Mackay, Duncan
Pierson, Sheila K




Drug repurposing
Journal Article
Systematic literature review


Date Revised 15.04.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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