High-Throughput Approach toward the Development of a Mizoroki-Heck Reaction To Access Tricyclic Spirolactones

The ent-kaurenes represent a class of naturally occurring diterpenes of biological importance. Several members of the ent-kaurenes contain a common, tricyclic spirolactone core as a key structural motif. This study details a concise approach toward the development of a Mizoroki-Heck reaction to access this spirolactone core. The strategy described herein was enabled in microscale high-throughput experiments to allow for the rapid identification and optimization of superior reaction conditions.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:85

Enthalten in:

The Journal of organic chemistry - 85(2020), 14 vom: 17. Juli, Seite 9071-9079

Sprache:

Englisch

Beteiligte Personen:

Annand, James R [VerfasserIn]
Riehl, Paul S [VerfasserIn]
Schultz, Danielle M [VerfasserIn]
Schindler, Corinna S [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 26.01.2021

Date Revised 26.01.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1021/acs.joc.0c00997

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311184723