Blog
Feedback
schliessen

Filtern

 

Bibliotheken

Logo der Bibliothek

Logo FID Pharmazie PubPharm Discovery System Universitätsbibliothek Braunschweig Institut für Informationssysteme

Non-linear relationships between seasonal exposure to polycyclic aromatic hydrocarbons and urinary 8-hydroxy-2'-deoxyguanosine levels among Chinese young students

Limited data are available on seasonal associations of polycyclic aromatic hydrocarbons (PAHs) exposure with oxidative DNA damage. We conducted a pilot study with 20 postgraduates, and measured urinary levels of mono-hydroxyl PAHs (OH-PAHs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) for 7 consecutive days in the four seasons. We assessed the relationships of urinary OH-PAHs with urinary 8-OHdG in the whole year as well as cold- and warm-seasons. Summed OH-PAHs (∑OH-PAHs) were higher in cold season than in warm season. Each ln-unit (ln-transformed unit) increase in ∑OH-PAHs in the whole year corresponded to a 34%, 16% or 23% increase in urinary 8-OHdG levels at lag0, lag1 or lag2 day as well as a 26% increase in urinary 8-OHdG levels at lag0-2 days (cumulative effects). Each ln-unit increase in ∑OH-PAHs corresponded to a 36%, 26% or 46% increase in urinary 8-OHdG levels in cold season at lag0 day, lag1 day or lag2 day as well as a 36% increase in urinary 8-OHdG in warm season at lag0 day. Distributed non-linear cumulative lag models (DLNMs) indicated that each ln-unit increase in ∑OH-PAHs within the range of 5.7-8.1 nmol/mmol Cr had a stronger effect (coefficient β: 1.11-2.97 nmol/mmol Cr) on urinary 8-OHdG rather than non-cumulative DLNMs (coefficient β: 1.08-1.43 nmol/mmol Cr) as well as the non-linear dose-response relationships of ∑OH-PAHs with urinary 8-OHdG. PAHs exposure exhibited the lagged and cumulative effects on urinary 8-OHdG levels

Year of Publication: 2020
Contained in: Chemosphere Vol. 251 (2020), p. 126352
All journal articles: Search for all articles in this journal
Language: English
Contributors: Huang, Yi-Dan | Author
Hou, Jian
Xu, Tian
Yin, Wen-Jun
Cheng, Juan
Zheng, Hong-Yan
Yuan, Jing
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: 8-OHdG
88847-89-6
Distributed lag non-linear model
G9481N71RO
Indoor air pollution
Journal Article
PAHs
Season
Additional Keywords: 8-Hydroxy-2'-Deoxyguanosine
Asian Continental Ancestry Group
Biomarkers
DNA Damage
Deoxyguanosine
Environmental Exposure
Female
Humans
Male
Pilot Projects
Polycyclic Aromatic Hydrocarbons
Seasons
Students
ISSN: 1879-1298
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Completed 18.06.2020
Date Revised 18.06.2020
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PMID:
    32443248
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1016/j.chemosphere.2020.126352
more publication details ...

Associated Publications

  • Associated records are being queried...
more (+)
Internes Format
LEADER 04543nma a2200889 c 4500
001 NLM311128440
003 DE-601
005 20200619214011.0
007 cr uuu---uuuuu
008 200523s2020 000 0 eng d
024 7 |a 10.1016/j.chemosphere.2020.126352  |2 doi 
028 5 2 |a pubmed20n1237.xml 
035 |a S0045-6535(20)30545-2 
035 |a (DE-599)NLM32443248 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Huang, Yi-Dan 
245 1 0 |a Non-linear relationships between seasonal exposure to polycyclic aromatic hydrocarbons and urinary 8-hydroxy-2'-deoxyguanosine levels among Chinese young students  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Date Completed 18.06.2020 
500 |a Date Revised 18.06.2020 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a Copyright © 2020 Elsevier Ltd. All rights reserved. 
520 |a Limited data are available on seasonal associations of polycyclic aromatic hydrocarbons (PAHs) exposure with oxidative DNA damage. We conducted a pilot study with 20 postgraduates, and measured urinary levels of mono-hydroxyl PAHs (OH-PAHs) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) for 7 consecutive days in the four seasons. We assessed the relationships of urinary OH-PAHs with urinary 8-OHdG in the whole year as well as cold- and warm-seasons. Summed OH-PAHs (∑OH-PAHs) were higher in cold season than in warm season. Each ln-unit (ln-transformed unit) increase in ∑OH-PAHs in the whole year corresponded to a 34%, 16% or 23% increase in urinary 8-OHdG levels at lag0, lag1 or lag2 day as well as a 26% increase in urinary 8-OHdG levels at lag0-2 days (cumulative effects). Each ln-unit increase in ∑OH-PAHs corresponded to a 36%, 26% or 46% increase in urinary 8-OHdG levels in cold season at lag0 day, lag1 day or lag2 day as well as a 36% increase in urinary 8-OHdG in warm season at lag0 day. Distributed non-linear cumulative lag models (DLNMs) indicated that each ln-unit increase in ∑OH-PAHs within the range of 5.7-8.1 nmol/mmol Cr had a stronger effect (coefficient β: 1.11-2.97 nmol/mmol Cr) on urinary 8-OHdG rather than non-cumulative DLNMs (coefficient β: 1.08-1.43 nmol/mmol Cr) as well as the non-linear dose-response relationships of ∑OH-PAHs with urinary 8-OHdG. PAHs exposure exhibited the lagged and cumulative effects on urinary 8-OHdG levels 
611 2 7 |a Journal Article  |2 gnd 
653 2 |a 8-Hydroxy-2'-Deoxyguanosine  |6 D000080242  |a *urine  |6 Q000652 
653 2 |a Asian Continental Ancestry Group  |6 D044466 
653 2 |a Biomarkers  |6 D015415  |a urine  |6 Q000652 
653 2 |a DNA Damage  |6 D004249 
653 2 |a Deoxyguanosine  |6 D003849  |a analogs & derivatives  |6 Q000031 
653 2 |a Environmental Exposure  |6 D004781  |a analysis  |6 Q000032  |a *statistics & numerical data  |6 Q000706 
653 2 |a Female  |6 D005260 
653 2 |a Humans  |6 D006801 
653 2 |a Male  |6 D008297 
653 2 |a Pilot Projects  |6 D010865 
653 2 |a Polycyclic Aromatic Hydrocarbons  |6 D011084  |a analysis  |6 Q000032  |a *metabolism  |6 Q000378 
653 2 |a Seasons  |6 D012621 
653 2 |a Students  |6 D013334 
655 7 |a 8-OHdG  |2 gnd 
655 7 |a Distributed lag non-linear model  |2 gnd 
655 7 |a Indoor air pollution  |2 gnd 
655 7 |a PAHs  |2 gnd 
655 7 |a Season  |2 gnd 
655 7 |a Biomarkers  |2 gnd 
655 7 |a Polycyclic Aromatic Hydrocarbons  |2 gnd 
655 7 |a 8-Hydroxy-2'-Deoxyguanosine  |2 gnd 
655 7 |a 88847-89-6  |2 gnd 
655 7 |a Deoxyguanosine  |2 gnd 
655 7 |a G9481N71RO  |2 gnd 
689 0 0 |A f  |a Journal Article 
689 0 |5 DE-601 
689 1 0 |a 8-OHdG 
689 1 1 |a Distributed lag non-linear model 
689 1 2 |a Indoor air pollution 
689 1 3 |a PAHs 
689 1 4 |a Season 
689 1 |5 DE-601 
689 2 0 |a Biomarkers 
689 2 1 |a Polycyclic Aromatic Hydrocarbons 
689 2 2 |a 8-Hydroxy-2'-Deoxyguanosine 
689 2 3 |A r  |a 88847-89-6 
689 2 4 |a Deoxyguanosine 
689 2 5 |A r  |a G9481N71RO 
689 2 |5 DE-601 
700 1 |a Hou, Jian 
700 1 |a Xu, Tian 
700 1 |a Yin, Wen-Jun 
700 1 |a Cheng, Juan 
700 1 |a Zheng, Hong-Yan 
700 1 |a Yuan, Jing 
773 0 8 |i in  |t Chemosphere  |g Vol. 251 (2020), p. 126352  |q 251<126352  |w (DE-601)NLM074699830  |x 1879-1298 
856 4 1 |u http://dx.doi.org/10.1016/j.chemosphere.2020.126352  |3 Volltext 
912 |a GBV_NLM 
951 |a AR 
952 |d 251  |j 2020  |b 22  |c 07  |h 126352