Nanoceria-curcumin conjugate : Synthesis and selective cytotoxicity against cancer cells under oxidative stress conditions

Copyright © 2020 Elsevier B.V. All rights reserved..

A water- and alcohol-soluble cerium oxide-curcumin conjugate was obtained by co-evaporation with poly(N-vinylpyrrolidone) (PVP). A nanocomposite consisting of hybrid organic-inorganic particles was stable in a wide range of pH values. Its properties were evaluated using nine cell lines: normal (MDBK, ST, Vero) and malignant (L929, T98G, HEp-2, A549, RIN-m5F, Hep G2). PVP-stabilised nanoceria was shown to inhibit autoxidation of curcumin, to enhance curcumin photostability, to promote bioaccumulation and to affect curcumin cytotoxicity and photocytotoxicity, depending on cell type, being more toxic to cancer cells in a selective manner. Under the conditions of UVA/UVC or H2O2-induced oxidative stress, the nanoceria-PVP-curcumin (NPC) conjugate was found to possess a selective cytotoxicity: it caused drastic inhibition of metabolic activity or a decrease in the total number of tumour cells, while in non-transformed cultures under the same conditions, the nanoceria-PVP-curcumin conjugate protected cells from these damaging factors. The NPC-conjugate, unlike curcumin itself, demonstrated a photosensitising effect in tumour cell cultures, while protecting non-transformed cultures from the damaging effects of UV radiation or oxidative stress. Based on the results obtained, we strongly believe that this novel hybrid material has enhanced characteristics compared to other curcumin formulations, and can be considered as a potent drug for biomedical applications, including cancer therapy.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:209

Enthalten in:

Journal of photochemistry and photobiology. B, Biology - 209(2020) vom: 15. Aug., Seite 111921

Sprache:

Englisch

Beteiligte Personen:

Zholobak, N M [VerfasserIn]
Shcherbakov, A B [VerfasserIn]
Ivanova, O S [VerfasserIn]
Reukov, V [VerfasserIn]
Baranchikov, A E [VerfasserIn]
Ivanov, V K [VerfasserIn]

Links:

Volltext

Themen:

30K4522N6T
619G5K328Y
Antineoplastic Agents
Ceric oxide
Cerium
Curcumin
IT942ZTH98
Journal Article

Anmerkungen:

Date Completed 07.06.2021

Date Revised 07.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.jphotobiol.2020.111921

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311108318