A discrete neuronal circuit induces a hibernation-like state in rodents
Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.
| Errataetall: |
CommentIn: Nature. 2020 Jul;583(7814):34-35. - PMID 32601488 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:583 |
|---|---|
| Enthalten in: |
Nature - 583(2020), 7814 vom: 11. Juli, Seite 109-114 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Takahashi, Tohru M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
0RH81L854J |
|---|
| Anmerkungen: |
Date Completed 23.07.2020 Date Revised 27.04.2021 published: Print-Electronic CommentIn: Nature. 2020 Jul;583(7814):34-35. - PMID 32601488 Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41586-020-2163-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM311073662 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM311073662 | ||
| 003 | DE-627 | ||
| 005 | 20231225141453.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41586-020-2163-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1036.xml |
| 035 | |a (DE-627)NLM311073662 | ||
| 035 | |a (NLM)32528181 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Takahashi, Tohru M |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A discrete neuronal circuit induces a hibernation-like state in rodents |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.07.2020 | ||
| 500 | |a Date Revised 27.04.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Nature. 2020 Jul;583(7814):34-35. - PMID 32601488 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Glutamine |2 NLM | |
| 650 | 7 | |a 0RH81L854J |2 NLM | |
| 700 | 1 | |a Sunagawa, Genshiro A |e verfasserin |4 aut | |
| 700 | 1 | |a Soya, Shingo |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Manabu |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Katsuyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Ishikawa, Kiyomi |e verfasserin |4 aut | |
| 700 | 1 | |a Yanagisawa, Masashi |e verfasserin |4 aut | |
| 700 | 1 | |a Hama, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Emi |e verfasserin |4 aut | |
| 700 | 1 | |a Miyawaki, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Sakimura, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Masayo |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Takeshi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature |d 1945 |g 583(2020), 7814 vom: 11. Juli, Seite 109-114 |w (DE-627)NLM000008257 |x 1476-4687 |7 nnns |
| 773 | 1 | 8 | |g volume:583 |g year:2020 |g number:7814 |g day:11 |g month:07 |g pages:109-114 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41586-020-2163-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 583 |j 2020 |e 7814 |b 11 |c 07 |h 109-114 | ||