Cholestasis after very preterm birth was associated with adverse neonatal outcomes but no significant long-term liver disease : A population-based study

© 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd..

AIM: To describe outcome linked to neonatal cholestasis in a defined cohort of very preterm infants.

METHODS: Population-based retrospective case-control study of preterm infants, gestational age <30 weeks, surviving for 28 days, in Stockholm County. Cholestasis was defined as conjugated bilirubin ≥30 μmol/L exceeding 20% of total level at least twice and graded as high if exceeding 100 μmol/L. Cholestatic cases were matched on gestational week with two non-cholestatic controls.

RESULTS: The incidence rate of cholestasis was 37/250 (14.8%), with increasing rates in lower gestational weeks. Perinatal factors associated with cholestasis were pre-eclampsia and being born small for gestational age. Cholestatic infants had three times more bronchopulmonary dysplasia and eight times more retinopathy of prematurity. The mortality was 13.5% in cholestatic infants versus 2.7% in controls (P = .040). All deceased cholestatic infants had high-grade cholestasis. No surviving infants developed chronic liver disease by 10 years of age.

CONCLUSION: Cholestasis was common in very preterm infants and linked to disease severity and adverse outcome. Cholestasis may be an independent risk factor for bronchopulmonary dysplasia and retinopathy of prematurity and more severe cholestasis associated with increased mortality. Cholestasis was not associated with chronic liver disease later in childhood.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:110

Enthalten in:

Acta paediatrica (Oslo, Norway : 1992) - 110(2021), 1 vom: 11. Jan., Seite 141-148

Sprache:

Englisch

Beteiligte Personen:

Teng, Jonas [VerfasserIn]
Bohlin, Kajsa [VerfasserIn]
Nemeth, Antal [VerfasserIn]
Fischler, Björn [VerfasserIn]

Links:

Volltext

Themen:

Bronchopulmonary dysplasia
Chronic liver disease
Journal Article
Neonatal intensive care
Neonatal mortality
Research Support, Non-U.S. Gov't
Retinopathy of prematurity

Anmerkungen:

Date Completed 14.05.2021

Date Revised 14.05.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/apa.15408

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM311038921