A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity
Solid-phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumor cell lines.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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Enthalten in: |
Bioconjugate chemistry - 31(2020), 7 vom: 15. Juli, Seite 1745-1749 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Cartwright, Oliver Charles [VerfasserIn] |
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Links: |
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Themen: |
3554-90-3 |
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Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1021/acs.bioconjchem.0c00282 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM310953502 |
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650 | 7 | |a Antigens, Tumor-Associated, Carbohydrate |2 NLM | |
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700 | 1 | |a Searcey, Mark |e verfasserin |4 aut | |
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