Microfluidic-based models to address the bone marrow metastatic niche complexity
Copyright © 2020 Elsevier Ltd. All rights reserved..
Bone marrow (BM) is a preferential metastatic site for solid cancers, contributing to higher morbidity and mortality among millions of oncologic patients worldwide. There are no current efficient therapies to minimize this health burden. Microfluidic based in vitro models emerge as powerful alternatives to animal testing, as well as promising tools for the development of personalized medicine solutions. The complexity associated with the BM metastatic niche originated a wide variety of microfluidic platforms designed to mimic this microenvironment. This review gathers the essential parameters to design an accurate in vitro microfluidic device, based on a comparative analysis of existing models created to address the different steps of the metastatic cascade.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:112 |
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| Enthalten in: |
Seminars in cell & developmental biology - 112(2021) vom: 11. Apr., Seite 27-36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ribeiro, Patrícia [VerfasserIn] |
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| Links: |
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| Themen: |
Bone marrow |
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| Anmerkungen: |
Date Completed 04.01.2022 Date Revised 04.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.semcdb.2020.05.015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310929601 |
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| 520 | |a Bone marrow (BM) is a preferential metastatic site for solid cancers, contributing to higher morbidity and mortality among millions of oncologic patients worldwide. There are no current efficient therapies to minimize this health burden. Microfluidic based in vitro models emerge as powerful alternatives to animal testing, as well as promising tools for the development of personalized medicine solutions. The complexity associated with the BM metastatic niche originated a wide variety of microfluidic platforms designed to mimic this microenvironment. This review gathers the essential parameters to design an accurate in vitro microfluidic device, based on a comparative analysis of existing models created to address the different steps of the metastatic cascade | ||
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| 700 | 1 | |a Moura, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Lamghari, Meriem |e verfasserin |4 aut | |
| 700 | 1 | |a Neto, Estrela |e verfasserin |4 aut | |
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