The effect of green coffee extract supplementation on anthropometric measures in adults : A comprehensive systematic review and dose-response meta-analysis of randomized clinical trials
Copyright © 2020 Elsevier Ltd. All rights reserved..
BACKGROUND AND AIM: Two meta-analyses summarized data on the effects of green coffee extract (GCE) supplementation on anthropometric measures. However, the accuracy of those meta-analyses is uncertain due to several methodological limitations. Therefore, we aimed to conduct a comprehensive systematic review and dose-response meta-analysis to summarize all available evidence on the effects of GCE supplementation on anthropometric measures by considering the main limitations in the previous meta-analyses.
METHODS: We searched available online databases for relevant publications up to January 2020, using relevant keywords. All randomized clinical trials (RCTs) investigating the effects of GCE supplementation, compared with a control group, on anthropometric measures [including body weight, body mass index (BMI), body fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR)] were included.
RESULTS: After identifying 1871 studies from our initial search, 15 RCTs with a total sample size of 897 participants were included in the systematic review and meta-analysis. We found a significant reducing effect of GCE supplementation on body weight (weighted mean difference (WMD): -1.23, 95 % CI: -1.64, -0.82 kg,P < 0.001), BMI (WMD: -0.48, 95 % CI: -0.78, -0.18 kg/m2, P = 0.001), and WC (WMD: -1.00, 95 % CI: -1.70, -0.29 cm, P = 0.006). No significant effect of GCE supplementation on body fat percentage and WHR was seen. In the dose-response analyses, there was no significant association between chlorogenic acid (CGA) dosage, as the main polyphenol in green coffee, and changes in anthropometric measures.
CONCLUSION: We found that GCE supplementation had a beneficial effect on body weight, BMI and WC. It provides a cost-effective and safe alternative for the treatment of obesity. Additional well-designed studies are required to further confirm our findings.
Errataetall: |
CommentIn: Complement Ther Med. 2020 Aug;52:102511. - PMID 32951757 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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Enthalten in: |
Complementary therapies in medicine - 51(2020) vom: 20. Juni, Seite 102424 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Asbaghi, Omid [VerfasserIn] |
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Links: |
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Themen: |
Abdominal obesity |
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Anmerkungen: |
Date Completed 02.11.2020 Date Revised 02.11.2020 published: Print-Electronic CommentIn: Complement Ther Med. 2020 Aug;52:102511. - PMID 32951757 Citation Status MEDLINE |
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doi: |
10.1016/j.ctim.2020.102424 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM310869420 |
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500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
520 | |a BACKGROUND AND AIM: Two meta-analyses summarized data on the effects of green coffee extract (GCE) supplementation on anthropometric measures. However, the accuracy of those meta-analyses is uncertain due to several methodological limitations. Therefore, we aimed to conduct a comprehensive systematic review and dose-response meta-analysis to summarize all available evidence on the effects of GCE supplementation on anthropometric measures by considering the main limitations in the previous meta-analyses | ||
520 | |a METHODS: We searched available online databases for relevant publications up to January 2020, using relevant keywords. All randomized clinical trials (RCTs) investigating the effects of GCE supplementation, compared with a control group, on anthropometric measures [including body weight, body mass index (BMI), body fat percentage, waist circumference (WC) and waist-to-hip ratio (WHR)] were included | ||
520 | |a RESULTS: After identifying 1871 studies from our initial search, 15 RCTs with a total sample size of 897 participants were included in the systematic review and meta-analysis. We found a significant reducing effect of GCE supplementation on body weight (weighted mean difference (WMD): -1.23, 95 % CI: -1.64, -0.82 kg,P < 0.001), BMI (WMD: -0.48, 95 % CI: -0.78, -0.18 kg/m2, P = 0.001), and WC (WMD: -1.00, 95 % CI: -1.70, -0.29 cm, P = 0.006). No significant effect of GCE supplementation on body fat percentage and WHR was seen. In the dose-response analyses, there was no significant association between chlorogenic acid (CGA) dosage, as the main polyphenol in green coffee, and changes in anthropometric measures | ||
520 | |a CONCLUSION: We found that GCE supplementation had a beneficial effect on body weight, BMI and WC. It provides a cost-effective and safe alternative for the treatment of obesity. Additional well-designed studies are required to further confirm our findings | ||
650 | 4 | |a Journal Article | |
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650 | 4 | |a Abdominal obesity | |
650 | 4 | |a Chlorogenic acid | |
650 | 4 | |a Green coffee | |
650 | 4 | |a Obesity | |
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700 | 1 | |a Sadeghian, Mehdi |e verfasserin |4 aut | |
700 | 1 | |a Rahmani, Sepideh |e verfasserin |4 aut | |
700 | 1 | |a Mardani, Mahnaz |e verfasserin |4 aut | |
700 | 1 | |a Khodadost, Mahmoud |e verfasserin |4 aut | |
700 | 1 | |a Maleki, Vahid |e verfasserin |4 aut | |
700 | 1 | |a Pirouzi, Aliyar |e verfasserin |4 aut | |
700 | 1 | |a Talebi, Sepide |e verfasserin |4 aut | |
700 | 1 | |a Sadeghi, Omid |e verfasserin |4 aut | |
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