Genomics and Liver Transplantation : Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection

Copyright © 2020 by the American Association for the Study of Liver Diseases..

Acute cellular rejection (ACR) is a common complication in liver transplantation recipients (LTRs), especially within the first 12 months, and it is associated with increased morbidity and mortality. Although abnormalities in standard liver biochemistries may raise the clinical suspicion for ACR, it lacks specificity, and invasive liver biopsies, which are associated with numerous risks, are required for definitive diagnoses. Biomarker discovery for minimally invasive tools for diagnosis and prognostication of ACR after liver transplantation (LT) has become a rapidly evolving field of research with a recent shift in focus to omics-based biomarker discovery. Although none are yet ready to replace the standard of care, there are several promising minimally invasive, blood-derived biomarkers that are under intensive research for the diagnosis of ACR in LTRs. These omics-based biomarkers, encompassing DNA, RNA, proteins, and metabolites, hold tremendous potential. Some are likely to become integrated into ACR diagnostic algorithms to assist clinical decision making with a high degree of accuracy that is cost-effective and reduces or even obviates the need for an invasive liver biopsy.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 26(2020), 10 vom: 17. Okt., Seite 1337-1350

Sprache:

Englisch

Beteiligte Personen:

Kohut, Taisa J [VerfasserIn]
Barandiaran, Jose F [VerfasserIn]
Keating, Brendan J [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers
Journal Article
Review

Anmerkungen:

Date Completed 18.03.2021

Date Revised 18.03.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/lt.25812

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310863104