Gelation of the internal core of liposomes as a strategy for stabilization and modified drug delivery I. Physico-chemistry study
Copyright © 2020 Elsevier B.V. All rights reserved..
Since the application of nanotechnology to drug delivery, both polymer-based and lipid-based nanocarriers have demonstrated clinical benefits, improving both drug efficacy and safety. However, to further address the challenges of the drug delivery field, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymer-based and lipid-based delivery systems in a single nanocarrier. Within this scenario, this work is aimed at developing novel hybrid vesicles following the recent strategy of modifying the internal structure of liposomes. Specifically, polyethylene glycol-dimethacrylate (PEG-DMA, molecular weight 750 or 4000), was entrapped within unilamellar liposomes made of hydrogenated soybean phosphatidylcholine/cholesterol, and photo-crosslinked, in order to transform the aqueous inner core of liposomes into a soft and elastic hydrogel. After appropriate optimization of the preparation and gelation procedures, the primary objective of this work was to analyze the effect of the molecular weight of PEG-DMA on the main properties of these Gel-in-Liposome (GiL) systems. Indeed, by varying the molecular weight of PEG-DMA also its hydrophilic/lipophilic balance was modified and different arrangements of the polymer within the structure of liposomes as well as different interaction with their membrane were obtained. Both polymers were found in the inner core of the liposomes, however, the more hydrophobic PEG750-DMA also formed localized clusters within the liposome membrane, whereas the more hydrophilic PEG4000-DMA formed a polymeric corona on the vesicle surface. Preliminary cytotoxicity studies were also performed to evaluate the biological safety of these GiL systems and their suitability as innovative materials drug delivery application.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:585 |
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| Enthalten in: |
International journal of pharmaceutics - 585(2020) vom: 30. Juli, Seite 119467 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Petralito, Stefania [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.03.2021 Date Revised 03.03.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijpharm.2020.119467 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310773121 |
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| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a Since the application of nanotechnology to drug delivery, both polymer-based and lipid-based nanocarriers have demonstrated clinical benefits, improving both drug efficacy and safety. However, to further address the challenges of the drug delivery field, hybrid lipid-polymer nanocomposites have been designed to merge the beneficial features of both polymer-based and lipid-based delivery systems in a single nanocarrier. Within this scenario, this work is aimed at developing novel hybrid vesicles following the recent strategy of modifying the internal structure of liposomes. Specifically, polyethylene glycol-dimethacrylate (PEG-DMA, molecular weight 750 or 4000), was entrapped within unilamellar liposomes made of hydrogenated soybean phosphatidylcholine/cholesterol, and photo-crosslinked, in order to transform the aqueous inner core of liposomes into a soft and elastic hydrogel. After appropriate optimization of the preparation and gelation procedures, the primary objective of this work was to analyze the effect of the molecular weight of PEG-DMA on the main properties of these Gel-in-Liposome (GiL) systems. Indeed, by varying the molecular weight of PEG-DMA also its hydrophilic/lipophilic balance was modified and different arrangements of the polymer within the structure of liposomes as well as different interaction with their membrane were obtained. Both polymers were found in the inner core of the liposomes, however, the more hydrophobic PEG750-DMA also formed localized clusters within the liposome membrane, whereas the more hydrophilic PEG4000-DMA formed a polymeric corona on the vesicle surface. Preliminary cytotoxicity studies were also performed to evaluate the biological safety of these GiL systems and their suitability as innovative materials drug delivery application | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Gelled-core liposomes | |
| 650 | 4 | |a Hybrid nanocarriers | |
| 650 | 4 | |a Hydrogels | |
| 650 | 4 | |a Membrane properties | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a Liposomes |2 NLM | |
| 650 | 7 | |a Methacrylates |2 NLM | |
| 650 | 7 | |a Phosphatidylcholines |2 NLM | |
| 650 | 7 | |a poly(ethylene glycol)-dimethacrylate |2 NLM | |
| 650 | 7 | |a polyethylene glycol monooctylphenyl ether |2 NLM | |
| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
| 650 | 7 | |a 3WJQ0SDW1A |2 NLM | |
| 650 | 7 | |a Cholesterol |2 NLM | |
| 650 | 7 | |a 97C5T2UQ7J |2 NLM | |
| 700 | 1 | |a Paolicelli, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Nardoni, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Trilli, Jordan |e verfasserin |4 aut | |
| 700 | 1 | |a Di Muzio, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Cesa, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Relucenti, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Matassa, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Vitalone, Annabella |e verfasserin |4 aut | |
| 700 | 1 | |a Adrover, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Casadei, Maria Antonietta |e verfasserin |4 aut | |
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