Chemoselective Electrochemical Hydrogenation of Ketones and Aldehydes with a Well-Defined Base-Metal Catalyst

© 2020 The Authors. Published by Wiley-VCH GmbH..

Hydrogenation reactions are fundamental functional group transformations in chemical synthesis. Here, we introduce an electrochemical method for the hydrogenation of ketones and aldehydes by in situ formation of a Mn-H species. We utilise protons and electric current as surrogate for H2 and a base-metal complex to form selectively the alcohols. The method is chemoselective for the hydrogenation of C=O bonds over C=C bonds. Mechanistic studies revealed initial 3 e- reduction of the catalyst forming the steady state species [Mn2 (H-1 L)(CO)6 ]- . Subsequently, we assume protonation, reduction and internal proton shift forming the hydride species. Finally, the transfer of the hydride and a proton to the ketone yields the alcohol and the steady state species is regenerated via reduction. The interplay of two manganese centres and the internal proton relay represent the key features for ketone and aldehyde reduction as the respective mononuclear complex and the complex without the proton relay are barely active.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

Chemistry (Weinheim an der Bergstrasse, Germany) - 26(2020), 62 vom: 06. Nov., Seite 14137-14143

Sprache:

Englisch

Beteiligte Personen:

Fokin, Igor [VerfasserIn]
Siewert, Inke [VerfasserIn]

Links:

Volltext

Themen:

Catalysis
Homogeneous catalysis
Journal Article
Molecular electrochemistry
Reaction mechanisms
Spectroelectrochemistry

Anmerkungen:

Date Revised 15.12.2020

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1002/chem.202002075

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310768977