C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems : a novel fragment collection
All-syn fused cyclobutanes remain an elusive chemotype and thus present an interesting synthetic challenge. Herein, we report the successful application of Pd-catalysed C(sp3)-H arylation of cyclobutane compounds to generate all-syn heterobicyclic fragments using an innovative 'inside-out' approach. Through this strategy we generate a virtual collection of 90 fragments, which we demonstrate to have enhanced three-dimensionality and superior fragment-like properties compared to existing collections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 56(2020), 54 vom: 07. Juli, Seite 7423-7426 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Osberger, Thomas J [VerfasserIn] |
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| Anmerkungen: |
Date Completed 07.07.2020 Date Revised 07.07.2020 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d0cc03237a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310706726 |
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| 520 | |a All-syn fused cyclobutanes remain an elusive chemotype and thus present an interesting synthetic challenge. Herein, we report the successful application of Pd-catalysed C(sp3)-H arylation of cyclobutane compounds to generate all-syn heterobicyclic fragments using an innovative 'inside-out' approach. Through this strategy we generate a virtual collection of 90 fragments, which we demonstrate to have enhanced three-dimensionality and superior fragment-like properties compared to existing collections | ||
| 650 | 4 | |a Journal Article | |
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