Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type : A Dose-Response Meta-Analysis of Observational Studies
© The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved..
AIMS: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.
METHODS: PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline.
RESULTS: A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake.
CONCLUSIONS: This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
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| Enthalten in: |
Alcohol and alcoholism (Oxford, Oxfordshire) - 55(2020), 5 vom: 14. Aug., Seite 457-467 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Xiaohui [VerfasserIn] |
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| Anmerkungen: |
Date Completed 10.06.2021 Date Revised 10.06.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/alcalc/agaa047 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310645093 |
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| 500 | |a Date Revised 10.06.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. All rights reserved. | ||
| 520 | |a AIMS: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender | ||
| 520 | |a METHODS: PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline | ||
| 520 | |a RESULTS: A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake | ||
| 520 | |a CONCLUSIONS: This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 700 | 1 | |a Chen, Jiahao |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Wenjie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Dongfeng |e verfasserin |4 aut | |
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