Omentin-1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high-fat diet-induced obese mice

© 2020 Société Française de Pharmacologie et de Thérapeutique..

Omentin-1 is an adipokine expressed by the adipose tissue and is reduced in obesity. This study was designed to calculate the protective efficiency and mechanism of omentin-1 against inflammation of the adipose tissue in obese mice. A transgenic mouse model with omentin-1 protein overexpression was established by crossing omentin-1 transgenic mice with Fabp4-Cre mice. Obesity was induced in the mice by feeding them a high-fat diet for 10 weeks. Fabp4-Cre-mediated overexpression of omentin-1 significantly increased serum omentin-1 level, serum anti-inflammatory factor levels, and expression of M2-specific mRNAs; inhibited body weight and adipose tissue weight gain; improved glucose tolerance, insulin tolerance, and insulin sensitivity; decreased serum levels of insulin and proinflammatory factors, adipocyte size, and expression of M1-specific mRNAs; suppressed macrophage infiltration; downregulated expression of proinflammatory factors; upregulated expression of anti-inflammatory factors; and inhibited thioredoxin-interacting protein (TXNIP)/NOD-like receptor 3 (NLRP3) signaling in the adipose tissue of obese mice. An NLRP3 inhibitor (20 mg/kg MCC950) exhibited the same effects as overexpression of omentin-1. Pretreatment with omentin-1 inhibited lipopolysaccharide-induced inflammation via TXNIP/NLRP3 signaling in RAW 264.7 macrophages. These findings suggest that omentin-1 suppresses adipose tissue inflammation in obese mice, at least partly, via inhibiting the TXNIP/NLRP3 signaling pathway.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:34

Enthalten in:

Fundamental & clinical pharmacology - 34(2020), 6 vom: 02. Dez., Seite 721-735

Sprache:

Englisch

Beteiligte Personen:

Zhou, Hongli [VerfasserIn]
Zhang, Zuo [VerfasserIn]
Qian, Guisheng [VerfasserIn]
Zhou, Jiyin [VerfasserIn]

Links:

Volltext

Themen:

52500-60-4
Adipokines
Adipose tissue
Carrier Proteins
Cytokines
GPI-Linked Proteins
Inflammation
Itln1 protein, mouse
Journal Article
Lectins
NLR Family, Pyrin Domain-Containing 3 Protein
Obese mice
Omentin-1
Overexpression
TXNIP/NLRP3 signaling pathway
Thioredoxins
Txnip protein, mouse

Anmerkungen:

Date Completed 26.07.2021

Date Revised 26.07.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1111/fcp.12575

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31060091X