Asymmetric Nitrogen-Containing Dimer from Aerial Parts of Mercurialis leiocarpa and Its Synthesis by Mimicking Generation Process through Radical Intermediates
An asymmetric nitrogen-containing dimer, leiocarpanine A, was isolated from the aerial part of Mercurialis leiocarpa as a new compound. The new generation process of leiocarpanine A was estimated and a concise synthesis of leiocarpanine A could be detailed based on mimicking the generation process through the radical intermediates. In general, a lot of reaction step and organic reagents are required for the synthesis of asymmetric nitrogen-containing dimers. However, our new synthesis method enables a concise synthesis of asymmetric nitrogen-containing dimers through radical intermediates by only liquid-separation. This synthetic method provides a rapid and concise pathway to construct a library of nitrogen-containing dimers that might be useful for drug discovery. In addition, it is useful to elucidate the generation process of leiocarpanine A.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
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| Enthalten in: |
Chemical & pharmaceutical bulletin - 68(2020), 6 vom: 25., Seite 520-525 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kondo, Yuto [VerfasserIn] |
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| Links: |
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| Themen: |
Dye plant |
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| Anmerkungen: |
Date Completed 11.01.2021 Date Revised 11.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1248/cpb.c20-00058 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310562902 |
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| 520 | |a An asymmetric nitrogen-containing dimer, leiocarpanine A, was isolated from the aerial part of Mercurialis leiocarpa as a new compound. The new generation process of leiocarpanine A was estimated and a concise synthesis of leiocarpanine A could be detailed based on mimicking the generation process through the radical intermediates. In general, a lot of reaction step and organic reagents are required for the synthesis of asymmetric nitrogen-containing dimers. However, our new synthesis method enables a concise synthesis of asymmetric nitrogen-containing dimers through radical intermediates by only liquid-separation. This synthetic method provides a rapid and concise pathway to construct a library of nitrogen-containing dimers that might be useful for drug discovery. In addition, it is useful to elucidate the generation process of leiocarpanine A | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Mercurialis leiocarpa | |
| 650 | 4 | |a dye plant | |
| 650 | 4 | |a isochrysohermidin | |
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| 650 | 4 | |a nitrogen-containing dimer | |
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| 700 | 1 | |a Nakamura, Seikou |e verfasserin |4 aut | |
| 700 | 1 | |a Ino, Sayaka |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Haruka |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Souichi |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuda, Hisashi |e verfasserin |4 aut | |
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