Association between Abdominal Obesity and Incident Colorectal Cancer : A Nationwide Cohort Study in Korea
BACKGROUND: We investigated the association of waist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults.
METHODS: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis.
RESULTS: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (p for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08-1.12)), colon (1.11, 1.09-1.13), and rectal cancer (1.08, 1.05-1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals.
CONCLUSION: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancers - 12(2020), 6 vom: 26. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nam, Ga Eun [VerfasserIn] |
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| Links: |
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| Themen: |
Abdominal obesity |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/cancers12061368 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310471443 |
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| 100 | 1 | |a Nam, Ga Eun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between Abdominal Obesity and Incident Colorectal Cancer |b A Nationwide Cohort Study in Korea |
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| 500 | |a Date Revised 28.09.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: We investigated the association of waist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults | ||
| 520 | |a METHODS: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis | ||
| 520 | |a RESULTS: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (p for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08-1.12)), colon (1.11, 1.09-1.13), and rectal cancer (1.08, 1.05-1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals | ||
| 520 | |a CONCLUSION: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a abdominal obesity | |
| 650 | 4 | |a body mass index | |
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| 650 | 4 | |a waist circumference | |
| 700 | 1 | |a Baek, Se-Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Hong Bae |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Kyungdo |e verfasserin |4 aut | |
| 700 | 1 | |a Kwak, Jung-Myun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Seon-Hahn |e verfasserin |4 aut | |
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