Sensitivity of total knee replacement wear to variability in motion and load input : A parametric finite element analysis study
© 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC..
Polyethylene wear remains a contributor to long term failure in total knee replacements (TKRs). Advances in materials have improved polyethylene wear rates, therefore further wear reductions require a better understanding of patient-specific factors that lead to wear. Variability of gait within patients is considerable and could lead to significant variability in wear rates that cannot be predicted by standard testing methods. An in-silico study was performed to investigate the influence of gait variability on TKR polyethylene wear. Nine characteristic peaks within the load and motion profiles used for TKR wear testing were varied 75% to 125% from baseline (ISO-14243-3:2014) to generate 310 unique waveforms. Wear was calculated for 1-million cycles using a finite element TKR wear model. From the results, a surrogate model was developed using multiple linear regression, and used to predict how wear changes due to dispersion of motion and force peaks within a) ±5%, the maximum allowable input tolerance of ISO, and b) ±25%, more reflective of patient gait inter-variability. The range of wear within the ±5% tolerance was 0.65 mm3 /million cycles and was 3.24 mm3 /million cycles within the ±25% variability more in line with the dispersion observed within patients. Although no one kinematic or kinetic peak dominated variability in TKR volumetric wear, variability within flexion/extension peaks were the largest contributor to wear rate variability. Interaction between the peaks of different waveforms was also important. This study, and future studies incorporating patient-specific data, could help to explain the connection between patient-specific gait factors and wear rates.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
|---|---|
| Enthalten in: |
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 38(2020), 7 vom: 21. Juli, Seite 1538-1549 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mell, Steven P [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9002-88-4 |
|---|
| Anmerkungen: |
Date Completed 09.11.2020 Date Revised 26.10.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/jor.24755 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM310404738 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM310404738 | ||
| 003 | DE-627 | ||
| 005 | 20231225140022.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jor.24755 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1034.xml |
| 035 | |a (DE-627)NLM310404738 | ||
| 035 | |a (NLM)32458460 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mell, Steven P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Sensitivity of total knee replacement wear to variability in motion and load input |b A parametric finite element analysis study |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.11.2020 | ||
| 500 | |a Date Revised 26.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC. | ||
| 520 | |a Polyethylene wear remains a contributor to long term failure in total knee replacements (TKRs). Advances in materials have improved polyethylene wear rates, therefore further wear reductions require a better understanding of patient-specific factors that lead to wear. Variability of gait within patients is considerable and could lead to significant variability in wear rates that cannot be predicted by standard testing methods. An in-silico study was performed to investigate the influence of gait variability on TKR polyethylene wear. Nine characteristic peaks within the load and motion profiles used for TKR wear testing were varied 75% to 125% from baseline (ISO-14243-3:2014) to generate 310 unique waveforms. Wear was calculated for 1-million cycles using a finite element TKR wear model. From the results, a surrogate model was developed using multiple linear regression, and used to predict how wear changes due to dispersion of motion and force peaks within a) ±5%, the maximum allowable input tolerance of ISO, and b) ±25%, more reflective of patient gait inter-variability. The range of wear within the ±5% tolerance was 0.65 mm3 /million cycles and was 3.24 mm3 /million cycles within the ±25% variability more in line with the dispersion observed within patients. Although no one kinematic or kinetic peak dominated variability in TKR volumetric wear, variability within flexion/extension peaks were the largest contributor to wear rate variability. Interaction between the peaks of different waveforms was also important. This study, and future studies incorporating patient-specific data, could help to explain the connection between patient-specific gait factors and wear rates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a computational analysis | |
| 650 | 4 | |a implant wear | |
| 650 | 4 | |a kinematics and gait | |
| 650 | 4 | |a total knee replacements | |
| 650 | 7 | |a Polyethylene |2 NLM | |
| 650 | 7 | |a 9002-88-4 |2 NLM | |
| 700 | 1 | |a Wimmer, Markus A |e verfasserin |4 aut | |
| 700 | 1 | |a Lundberg, Hannah J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of orthopaedic research : official publication of the Orthopaedic Research Society |d 1993 |g 38(2020), 7 vom: 21. Juli, Seite 1538-1549 |w (DE-627)NLM012903639 |x 1554-527X |7 nnns |
| 773 | 1 | 8 | |g volume:38 |g year:2020 |g number:7 |g day:21 |g month:07 |g pages:1538-1549 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/jor.24755 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 38 |j 2020 |e 7 |b 21 |c 07 |h 1538-1549 | ||